发明授权
US4673692A Diphenylmethylimine derivatives, their compositions and pharmaceutical
uses
失效
二苯基亚甲基衍生物,其组成和药物用途
- 专利标题: Diphenylmethylimine derivatives, their compositions and pharmaceutical uses
- 专利标题(中): 二苯基亚甲基衍生物,其组成和药物用途
-
申请号: US789275申请日: 1985-10-18
-
公开(公告)号: US4673692A公开(公告)日: 1987-06-16
- 发明人: Yasushi Suzuki , Yukio Hasegawa , Michitaka Sato , Morinobu Saito , Norio Yamamoto , Katsuhiko Miyasaka , Takashi Mikami , Katsuhiko Miyazawa
- 申请人: Yasushi Suzuki , Yukio Hasegawa , Michitaka Sato , Morinobu Saito , Norio Yamamoto , Katsuhiko Miyasaka , Takashi Mikami , Katsuhiko Miyazawa
- 申请人地址: JPX Tokyo
- 专利权人: Teikoku Hormone Mfg. Co., Ltd.
- 当前专利权人: Teikoku Hormone Mfg. Co., Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX59-218679 19841019
- 主分类号: C12N9/99
- IPC分类号: C12N9/99 ; A61K31/135 ; A61K31/15 ; A61K31/175 ; A61K31/19 ; A61K31/22 ; A61P9/00 ; A61P9/08 ; A61P9/10 ; A61P11/00 ; A61P25/04 ; A61P29/00 ; A61P35/00 ; A61P37/00 ; A61P37/08 ; A61P43/00 ; C07C251/32 ; C07C251/48 ; C07C251/58 ; C07C251/60 ; C07C251/64 ; C07C131/00
摘要:
A compound represented by the formula ##STR1## wherein R.sup.1 represents a hydroxyl group, an alkanoyloxy group or a group of the formula ##STR2## in which R.sup.2 represents a hydrogen atom or a lower alkyl group, and R.sup.3 represents a hydrogen atom, a lower alkyl group, an alkanoyl group, a phenyl group, a carbamoyl group or a thiocarbamoyl group, or a salt thereof.The said compound can be prepared by reacting a compound represented by the formula ##STR3## with a compound of the formulaNH.sub.2 --R.sup.1 (III)wherein R.sup.1 is as defined hereinabove, or a salt thereof, and as required, alkanoylating the resulting compound of formula (I) in which R.sup.1 represents a hydroxyl group or an amino group, and as required, converting the resulting compound of formula (I) in which R.sup.1 is the group ##STR4## into its salt, and is useful for the treatment of inflammation, pain or rheumatism.
公开/授权文献
信息查询