公开(公告)号：US4782086A

公开(公告)日：1988-11-01

申请号：US17297

申请日：1987-02-20

Applicant: Winfried Lunkenheimer ,  Hans Scheinpflug ,  Wilhelm Brandes

Inventor： Winfried Lunkenheimer ,  Hans Scheinpflug ,  Wilhelm Brandes

IPC: A01N37/50 ,  A01N41/10 ,  A01N43/36 ,  A01N43/653 ,  A01N47/24 ,  C07C249/04 ,  C07C281/06 ,  C07C317/00 ,  C07D207/16 ,  C07D249/08 ,  C07D295/18 ,  C07D295/185 ,  C07D521/00 ,  C07K5/06 ,  A01N37/34 ,  A01N37/46 ,  C07C131/00

CPC classification number: C07D295/185 ,  A01N37/50 ,  A01N41/10 ,  A01N43/36 ,  A01N43/653 ,  A01N47/24 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07K5/06052

Abstract: Fungicidally active novel E-isomers of N.sup..alpha. -(2-cyano-2-alkoximino-acetyl)-amino acid derivatives and peptides of the general formula (I) ##STR1## in which R represents alkyl, alkenyl, alkinyl, cyanoalkyl, azolylalkyl or optionally substituted phenylalkyl, or represents optionally substituted cycloalkyl;R.sup.1 represents hydrogen, alkyl, optionally substituted phenyl or optionally substituted benzyl, or represents alkoxycarbonylamino;R.sup.2 represents hydrogen or alkyl;R.sup.3 represents hydrogen, alkyl, alkoxycarbonylalkyl, hydroxycarbonylalkyl, aminocarbonylalkyl, azolylalkyl, cyanoalkyl, hydroxyalkyl, alkenyl, alkinyl or optionally substituted cycloalkyl, or represents optionally substituted phenyl or phenylalkyl, or represents the groupingR.sup.4 --SO.sub.n --Z--R.sup.4 n and Z having various meanings, andX is --OH--OR.sup.1 or --NR.sup.2 R.sup.3.

Abstract translation: Nα - （2-氰基-2-肟基 - 乙酰基） - 氨基酸衍生物的杀真菌活性新型E-异构体和通式（I）的肽其中R表示烷基，烯基，炔基， 氰基烷基，唑基烷基或任选取代的苯基烷基，或表示任选取代的环烷基; R 1表示氢，烷基，任选取代的苯基或任选取代的苄基，或表示烷氧基羰基氨基; R2代表氢或烷基; R 3表示氢，烷基，烷氧基羰基烷基，羟基羰基烷基，氨基羰基烷基，唑基烷基，氰基烷基，羟烷基，烯基，炔基或任选取代的环烷基，或表示任选取代的苯基或苯基烷基，或表示具有各种 含义，X为-OH-OR 1或-NR 2 R 3。

公开(公告)号：US4709095A

公开(公告)日：1987-11-24

申请号：US853809

申请日：1986-03-25

Applicant: Tsutomu Yamanaka ,  Osamu Yaoka

Inventor： Tsutomu Yamanaka ,  Osamu Yaoka

IPC: A61K31/15 ,  A61K31/35 ,  A61K31/352 ,  A61K31/47 ,  A61P7/10 ,  A61P9/12 ,  A61P25/04 ,  A61P29/00 ,  C07C67/00 ,  C07C239/00 ,  C07C251/48 ,  C07D215/42 ,  C07D311/68 ,  C07C131/00

CPC classification number: C07D311/68

Abstract: Ortho-aminomethylphenol compounds of the formula: ##STR1## wherein X is hydrogen or halogen, R is hydrogen or alkyl having 1 to 4 carbon atoms and A is alkyl having 1 to 4 carbon atoms, phenyl, benzyl or a bivalent radical selected from --(CH.sub.2).sub.3 -- and --O(CH.sub.2).sub.2 -- and joined together with the 3 or 5 position of the benzene nucleus to form a bicycle, or pharmaceutically acceptable salts thereof, a method of preparing said compounds and a pharmaceutical composition containing said compounds, are disclosed.Such compounds exhibit antiinflammatory, analgesic, diuretic and antihypertensive activities, so they are useful in the treatment for diseases caused by inflammation, edema or hypertension.

Abstract translation: PCT No.PCT / JP85 / 00440 Sec。 371日期：1986年3月25日 102（e）日期1986年3月25日PCT提交1985年8月2日PCT公布。 出版物WO86 / 01201 日本：1986年2月27日。下式的邻氨基甲基苯酚化合物：其中X是氢或卤素，R是氢或具有1至4个碳原子的烷基，A是具有1至4个碳原子的烷基，苯基，苄基 或选自 - （CH 2）3 - 和-O（CH 2）2 - 的二价基团并且与苯核的3或5位相连接以形成自行车或其药学上可接受的盐，制备所述化合物的方法 和含有所述化合物的药物组合物。 这些化合物表现出抗炎，止痛，利尿和抗高血压活性，因此它们可用于治疗由炎症，水肿或高血压引起的疾病。

公开(公告)号：US4705782A

公开(公告)日：1987-11-10

申请号：US844146

申请日：1986-03-26

Applicant: Robert T. Logan ,  James Redpath ,  Robert G. Roy

Inventor： Robert T. Logan ,  James Redpath ,  Robert G. Roy

IPC: A61K31/16 ,  A61K31/175 ,  A61K31/335 ,  A61K31/357 ,  A61P9/04 ,  C07C67/00 ,  C07C239/00 ,  C07C257/10 ,  C07C259/06 ,  C07C259/18 ,  C07C281/16 ,  C07C281/18 ,  C07D317/70 ,  C07C93/10 ,  A61K31/05 ,  A61K31/155 ,  C07C131/00

CPC classification number: C07C259/18 ,  C07C281/18

Abstract: The invention relates to compounds of the general formula I ##STR1## wherein R.sub.1 represents one up to and including four, the same or different substituents selected from alkyl(1-6 C), alkoxy(1-6 C), hydroxy, halogen, NO.sub.2, CF.sub.3 or the group --NR.sub.5 R.sub.6,whereby two substituents taken together may also represent a methylene-dioxy group,X represents a member selected from ##STR2## --CH.sub.2 --CH.sub.2 -- and --CH.dbd.CH--, n has the value 0, 1 or 2,R.sub.3 represents one of the moieties: ##STR3## and R.sub.2, R.sub.4, R.sub.5 and R.sub.6 represent hydrogen or alkyl(1-6 C),and pharmaceutically acceptable salts thereof, suitable in the treatment of heartfailure.

Abstract translation: 本发明涉及通式Ⅰ的化合物，其中R 1代表一个至多并包括四个相同或不同的选自烷基（1-6C），烷氧基（1-6C），羟基，卤素， NO 2，CF 3或基团-NR 5 R 6，其中两个取代基一起也可以表示亚甲基 - 二氧基，X表示选自R4CH，+ RF-CH2-CH2-和-CH = CH-的成员，n的值为0 ，1或2，R 3表示下列部分之一：其中R2，R4，R5和R6代表氢或烷基（1-6C）及其药学上可接受的盐，适用于治疗心脏衰竭。

公开(公告)号：US4697038A

公开(公告)日：1987-09-29

申请号：US587068

申请日：1984-03-07

Applicant: John H. P. Tyman

Inventor： John H. P. Tyman

IPC: C07C37/86 ,  C07C131/00

CPC classification number: C07C37/86 ,  C07C37/004

Abstract: Compounds of the formula ##STR1## in which; X represents a straight chain hydrocarbyl group containing from 8 to 17 carbon atoms;Y represents H or the group--CH.dbd.NOH, andZ represents H or the group--CH.dbd.NOH or the group--CPh.dbd.NOH,provided that at least one of Y and Z represents H; or such compound containing at least one electronegative substituent in the aromatic ring, may be prepared from anacardic acid and its analogues, and are useful for the extraction of copper from acidic aqueous solution. Cardanol, which has the formula ##STR2## where n=0, 2, 4 or 6 is recovered from cashew nut shell liquid containing cardol and other dihydric phenols by reacting the dihydric phenols in the CNSL with an aldehyde while leaving the cardanol substantially unreacted, and vacuum distilling the cardanol from the reaction mixture.

Abstract translation: 式中的化合物其中; X表示含有8〜17个碳原子的直链烃基; Y表示H或基团-CH = NOH，Z表示H或基团-CH = NOH或基团-ch = NOH，条件是Y和Z中的至少一个表示H; 或在芳香环中含有至少一个电负性取代基的这种化合物可以由漆树酸及其类似物制备，并且可用于从酸性水溶液中提取铜。 通过使CNSL中的二元酚与醛反应而使腰果酚基本上未反应，通过使含有卡诺尔和其它二元酚的腰果壳液回收含有n = 0,4,4或6的式“ 并将真空从反应混合物中蒸馏出来。

公开(公告)号：US4622427A

公开(公告)日：1986-11-11

申请号：US653386

申请日：1984-09-21

Applicant: Bernd Baasner ,  Heinz Ziemann ,  Erich Klauke

Inventor： Bernd Baasner ,  Heinz Ziemann ,  Erich Klauke

IPC: C07B61/00 ,  B01J23/00 ,  B01J23/40 ,  B01J23/74 ,  B01J25/00 ,  B01J25/02 ,  C07C67/00 ,  C07C239/00 ,  C07C239/08 ,  C07C251/34 ,  C07C131/00

CPC classification number: C07C249/10 ,  C07C239/10

Abstract: Partially hydrogenated derivatives of 2-nitro-1,1,1-trifluoroalkanes, in particular 2-oximino- and 2-hydroxylamino-1,1,1-trifluoroalkanes, are prepared by catalytically hydrogenating 2-nitro-1,1,1-trifluoroalkanes until a maximum of 2.2 moles of hydrogen per mole of 2-nitro-1,1,1-trifluoroalkane have reacted.

Abstract translation: 通过催化氢化2-硝基-1,1,1-三氟烷烃的2-硝基-1,1,1-三氟烷烃，特别是2-肟基和2-羟基氨基-1,1,1-三氟烷烃的部分氢化衍生物， 直到每摩尔2-硝基-1,1,1-三氟烷烃最多达2.2摩尔氢气已反应。

公开(公告)号：US4594446A

公开(公告)日：1986-06-10

申请号：US690989

申请日：1985-01-14

Applicant: Ikuo Ueda ,  Takao Takaya ,  Masakazu Kobayashi ,  Takashi Masugi ,  Hisashi Takasugi ,  Hiromu Kochi ,  Tadashi Kitaguchi

Inventor： Ikuo Ueda ,  Takao Takaya ,  Masakazu Kobayashi ,  Takashi Masugi ,  Hisashi Takasugi ,  Hiromu Kochi ,  Tadashi Kitaguchi

IPC: C07D317/30 ,  C07D319/06 ,  C07D501/04 ,  C07D501/14 ,  C07D501/20 ,  C07C131/00 ,  C07D317/14 ,  C07D321/00 ,  C07F7/04

CPC classification number: C07D317/30 ,  C07D319/06

Abstract: The invention relates to new antimicrobially active 3-cephem compounds, processes for preparing such compounds, new intermediate compounds comprising alkoxyimino dioxy butyric acid derivatives useful in said processes, and processes for preparation of said intermediates.

公开(公告)号：US4584403A

公开(公告)日：1986-04-22

申请号：US584181

申请日：1984-02-27

Applicant: Dennis K. Krass

Inventor： Dennis K. Krass

IPC: A01N37/38 ,  C07C131/00

CPC classification number: A01N37/38

Abstract: This invention relates to certain herbicidally active substituted diphenyl ether oxime derivatives, herbicidal compositions of the same and the use thereof for preemergence and postemergence control of noxious plants, i.e., weeds.

公开(公告)号：US4560797A

公开(公告)日：1985-12-24

申请号：US451701

申请日：1982-12-20

Applicant: Jean Yamanis ,  Emery J. Carlson ,  John N. Armor

Inventor： Jean Yamanis ,  Emery J. Carlson ,  John N. Armor

IPC: B01J23/30 ,  B01J27/188 ,  B01J37/03 ,  C07C131/04 ,  B01J23/92 ,  C07C131/00

CPC classification number: B01J27/188 ,  B01J23/30 ,  B01J37/033

Abstract: Improved processes for the conversion to oximes by selective oxidation, in the vapor phase, of saturated primary aliphatic or alicyclic amines having 2 to 12 carbon atoms especially cyclohexylamine to cyclohexanone oxime with elemental oxygen, in a reaction zone, in the presence of an effective amount of a catalyst comprising an oxygen-containing tungsten compound and alumina by (1) periodically regenerating the oxygen-containing tungsten catalyst by heating same at about 250.degree. C.-300.degree. C. in the presence of elemental oxygen, or (2) maintaining the temperature of the oxygen-containing tungsten catalyst in a range of about 100.degree. C.-145.degree. C. or (3) employing higher mol fractions of oxygen and of amine in a range of about 0.2-0.4 in the vapor phase are disclosed. An improved method of preparing an oxygen-containing tungsten on an alumina catalyst is also disclosed.

Abstract translation: 在有效量的存在下，在反应区中，通过在气相中选择性氧化具有2至12个碳原子的饱和伯脂族或脂环族胺，特别是环己胺与环己酮肟与元素氧的转化为肟的改进方法 包含含氧钨化合物和氧化铝的催化剂通过（1）在元素氧存在下，在约250℃-300℃下，通过加热氧化钨催化剂来定期再生含氧钨催化剂，或者（2）维持 公开了含氧钨催化剂在约100℃-145℃范围内的温度或（3）在汽相中使用较高摩尔分数的氧气和约0.2-0.4范围的胺的胺 。 还公开了一种在氧化铝催化剂上制备含氧钨的改进方法。

公开(公告)号：US4469889A

公开(公告)日：1984-09-04

申请号：US541367

申请日：1983-10-12

Applicant: Lawrence L. Martin ,  Manfred Worm ,  Charles A. Crichlow

Inventor： Lawrence L. Martin ,  Manfred Worm ,  Charles A. Crichlow

IPC: C07D243/04 ,  C07C131/00

CPC classification number: C07D243/04 ,  C07C205/45 ,  C07C211/29 ,  C07C211/49 ,  C07C217/58 ,  C07C217/80 ,  C07C225/16 ,  C07C233/13 ,  C07C233/18 ,  C07C233/59 ,  C07C233/66 ,  C07C251/48 ,  C07C251/66 ,  C07C2101/14

Abstract: Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.

Abstract translation: 描述了新的4-苯基-1,3-苯并二氮杂，其新颖的中间体及其制备方法。 这些苯二氮卓类可用作抗抑郁药，止痛药和抗惊厥药。

公开(公告)号：US4455438A

公开(公告)日：1984-06-19

申请号：US376988

申请日：1982-05-10

Applicant: Laurenz Gsell ,  Jean-Claude Gehret

Inventor： Laurenz Gsell ,  Jean-Claude Gehret

IPC: A01N47/24 ,  C07C131/00

CPC classification number: A01N47/24

Abstract: Cyclobutanone oxime carbamates of the formula ##STR1## wherein n is 1 to 5 and X.sub.1 is hydrogen, halogen, C.sub.1 -C.sub.4 alkoxy or C.sub.1 -C.sub.4 alkylthio. A process for obtaining the compounds of the formula I and their use in pest control as well as the cyclobutanone oximes used as intermediates are described.

Abstract translation: 式（I）的环丁酮肟氨基甲酸酯，其中n为1至5，X 1为氢，卤素，C 1 -C 4烷氧基或C 1 -C 4烷硫基。 描述了获得式I化合物及其在病虫害防治中的用途以及用作中间体的环丁酮肟的方法。