发明授权
- 专利标题： Novel physiologically active substance MH435
- 专利标题（中）： 新型生理活性物质MH435
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申请号： US879069申请日： 1986-06-26
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公开(公告)号： US4686308A公开(公告)日： 1987-08-11
- 发明人: Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Hiroshi Naganawa , Tsutomu Sawa , Masaya Imoto , Hironobu Iinuma , Takeshi Uchida , Kunio Isshiki
- 申请人： Hamao Umezawa , Tomio Takeuchi , Masa Hamada , Hiroshi Naganawa , Tsutomu Sawa , Masaya Imoto , Hironobu Iinuma , Takeshi Uchida , Kunio Isshiki
- 申请人地址： JPX Tokyo
- 专利权人： Microbial Chemistry Research Foundation
- 当前专利权人： Microbial Chemistry Research Foundation
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX60-147039 19850704
- 主分类号： C12P13/02
- IPC分类号： C12P13/02 ; A61K31/16 ; A61P31/04 ; A61P35/00 ; C07C67/00 ; C07C231/00 ; C07C233/18 ; C07C233/22 ; C12P13/00 ; C12R1/465 ; C07C103/34
摘要：
Disclosed is a novel physiologically active substance, MH435, represented by the formula: ##STR1## wherein R represents either of the following groups A and B A: --CH.dbd.CH--NHCHOB: --CH.sub.2 --CH.sub.2 --NHCHO.The substance MH435 has an inhibitory activity against tyrosine specific protein kinase, and the 50% inhibitory concentrations of the substances MH435-A and MH435-B are respectively 0.55 .mu.g/ml and 6.0 .mu.g/ml.
公开/授权文献
- US5950223A Dual-edge extended data out memory 公开/授权日：1999-09-07
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