A polyurethane resin composition, which comprises (A) a urethane prepolymer composition containing 0.5 to 15.0% by weight of an active isocyanate group which is prepared by reacting a polyoxyalkylene ether polyol and/or polyester polyol and an excess amount of a polyisocaylante compound, and (B) as an adhesion-promoting agent 0.05 to 5.0% by weight of a reaction product of an amine compound containing at least one alkoxysilyl group of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are each a alkyl having 1 to 4 carbon atoms, and n is 0, 1 or 2, and an excess amount of a carbonyl compound. Said polyurethane resin composition has excellent adhesion properties and can show also excellent adhesiveness to metals which are hardly adhered with the conventional compositions and is useful as an adhesive, sealant and coating agent in various technical fields.