发明授权
US4704385A 3-formamido azetidinone antibacterial agents, their preparation and use
失效
3-甲酰氨基氮杂环丁酮抗菌剂，其制备和用途
- 专利标题： 3-formamido azetidinone antibacterial agents, their preparation and use
- 专利标题（中）： 3-甲酰氨基氮杂环丁酮抗菌剂，其制备和用途
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申请号： US835346申请日： 1986-03-03
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公开(公告)号： US4704385A公开(公告)日： 1987-11-03
- 发明人: Roger J. Ponsford , Michael J. Pearson , Stephen C. Finch
- 申请人： Roger J. Ponsford , Michael J. Pearson , Stephen C. Finch
- 申请人地址： GB2
- 专利权人： Beecham Group p.l.c.
- 当前专利权人： Beecham Group p.l.c.
- 当前专利权人地址： GB2
- 优先权： GBX8201752 19820122
- 主分类号： C07D205/08
- IPC分类号： C07D205/08 ; A61K31/395 ; A61K31/397 ; A61K31/425 ; A61P31/04 ; C07D205/085 ; C07D403/04 ; C07D403/12 ; C07D409/12 ; C07D417/12 ; C07F7/10 ; C07F7/18 ; C07F9/568 ; C07D401/12
摘要：
A monocyclic .beta.-lactam antibiotic having a formamido substituent at the 3S-position, including compounds of the formula (I): ##STR1## and salts thereof wherein R is --SO.sub.3 H; --PO(OH)Y wherein Y is C.sub.1-6 alkoxy, hydroxy, aryloxy, C.sub.1-6 alkyl or aryl; ##STR2## wherein Z represents C.sub.1-6 alkyl or aryl; ##STR3## wherein Z.sup.1 and Z.sup.2 may be the same or different and each represents hydrogen, C.sub.1-6 alkyl, aryl, amino or C.sub.1-6 alkoxy, or Z.sup.1 and Z.sup.2 together form the residue of a heterocyclic ring; --OSO.sub.3 H; or ##STR4## where X is hydrogen or hydroxy; R.sup.1 is an amino, protected amino or carboxylic acylamino group, and R.sup.2 and R.sup.3 are independently selected from hydrogen or a hydrocarbon group of 1 to 18 carbon atoms.