发明授权
- 专利标题： 2-chloronicergoline having antihypoxic activity
- 专利标题（中）： 具有抗低氧活性的2-氯麦角林
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申请号： US877294申请日： 1986-06-23
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公开(公告)号： US4753949A公开(公告)日： 1988-06-28
- 发明人: Gabor Megyeri , Tibor Keve , Bala Stefko , Erik Bogsch , Janos Galambos , Anna Kassi nee Zieger , Ferenc Trischler , Eva Palosi , Dora Groo , Egon Karpati , Zsolt Szombathelyi , Laszlo Szporny , Bela Kiss , Istvan Laszlovszky , Erzsebet Lapis
- 申请人： Gabor Megyeri , Tibor Keve , Bala Stefko , Erik Bogsch , Janos Galambos , Anna Kassi nee Zieger , Ferenc Trischler , Eva Palosi , Dora Groo , Egon Karpati , Zsolt Szombathelyi , Laszlo Szporny , Bela Kiss , Istvan Laszlovszky , Erzsebet Lapis
- 申请人地址： HUX Budapest
- 专利权人： Richter Gedeon Vegyeszeti Gyar Rt.
- 当前专利权人： Richter Gedeon Vegyeszeti Gyar Rt.
- 当前专利权人地址： HUX Budapest
- 优先权： HUX2447/85 19850621
- 主分类号： A61K31/48
- IPC分类号： A61K31/48 ; A61P3/00 ; A61P3/14 ; A61P9/00 ; A61P25/02 ; A61P25/28 ; C07D457/02
摘要：
The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), ##STR1## wherein X stands for chlorine, bromine or iodine atom, as well as their acid addition salts.The process of the invention comprises esterifying a novel 2-halo-1-methyllumilysergol of the formula (II), ##STR2## wherein X is the same as defined above, or an acid addition salt thereof and, if desired, converting the thus-obtained 2-halonicergoline derivative of the formula (I) to an acid addition salt.The compounds of the invention improve the cognitive function of the brain and show an antihypoxic as well as a strong .alpha.-adrenerg blocking and calcium-antagonistic action.
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