发明授权
US4757083A Novel pyrrolidinylamide ester derivatives having anti-prolyl
endopeptidase activity and synthesis and use thereof
失效
具有抗脯氨酰内肽酶活性的新型吡咯烷酰胺酯衍生物及其合成和用途
- 专利标题： Novel pyrrolidinylamide ester derivatives having anti-prolyl endopeptidase activity and synthesis and use thereof
- 专利标题（中）： 具有抗脯氨酰内肽酶活性的新型吡咯烷酰胺酯衍生物及其合成和用途
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申请号： US936445申请日： 1986-12-01
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公开(公告)号： US4757083A公开(公告)日： 1988-07-12
- 发明人: Naoki Higuchi , Masayuki Saitoh , Masaki Hashimoto , Harukazu Fukami , Takaharu Tanaka
- 申请人： Naoki Higuchi , Masayuki Saitoh , Masaki Hashimoto , Harukazu Fukami , Takaharu Tanaka
- 申请人地址： JPX Osaka
- 专利权人： Suntory Limited
- 当前专利权人： Suntory Limited
- 当前专利权人地址： JPX Osaka
- 优先权： JPX60-268994 19851129
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; A61K31/40 ; A61K31/401 ; A61P25/00 ; A61P43/00 ; C07D295/10 ; C07D295/185 ; C12N9/99 ; C07D295/18
摘要：
A novel pyrrolidinylamide ester derivative that exhibits inhibitory activity against prolyl endopeptidase, methods for synthesis thereof and its use as an inhibitor against said enzyme are disclosed. The pyrrolidinylamide ester of the invention has the following general formula: ##STR1## wherein n is 0 or an integer of 1 to 7 and R is hydrogen atom or a straight or branched alkyl having 1 to 8 carbon atoms.