发明授权
US4778800A 3-oxadiazole and 3-carboxylic acid beta-carboline derivatives, and their
use as psychotropic agents
失效
3-恶二唑和3-羧酸β-咔啉衍生物，以及它们作为精神药物的用途
- 专利标题： 3-oxadiazole and 3-carboxylic acid beta-carboline derivatives, and their use as psychotropic agents
- 专利标题（中）： 3-恶二唑和3-羧酸β-咔啉衍生物，以及它们作为精神药物的用途
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申请号： US929866申请日： 1986-11-13
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公开(公告)号： US4778800A公开(公告)日： 1988-10-18
- 发明人: Andreas Huth , Ralph Schmiechen , David N. Stephens , Mogens Engelstoft , Frank Waetjen , John B. Hansen , Leif H. Jensen
- 申请人： Andreas Huth , Ralph Schmiechen , David N. Stephens , Mogens Engelstoft , Frank Waetjen , John B. Hansen , Leif H. Jensen
- 申请人地址： DEX Berlin and Bergkamen
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： DEX Berlin and Bergkamen
- 优先权： DEX3540653 19851113
- 主分类号： A61K31/435
- IPC分类号： A61K31/435 ; A61P25/08 ; A61P25/20 ; C07D471/04 ; A61K31/40
摘要：
Compounds of formula I ##STR1## wherein X is COOR.sup.3 or an oxadiazolyl radical of the formula orR.sup.2 is H, lower alkyl or cycloalkyl,R.sup.3 is lower alkyl,R.sup.4 is hydrogen, lower alkyl or lower alkoxyalkyl,R.sup.A is -CHR.sup.1 -Z-R.sup.5,Z is sulfur or oxygen,R.sup.1 is lower alkyl or optionally substituted phenyl, and R.sup.5 is hydrogen, phenyl or optionally substituted lower alkyl,and wherein each compound can contain 1 or 2 R.sup.A radicals have valuable pharmacological properties.
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