发明授权
- 专利标题： Process for the stereospecific synthesis of indole derivatives
- 专利标题（中）： 吲哚衍生物的立体有择合成方法
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申请号： US67273申请日： 1987-06-29
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公开(公告)号： US4806655A公开(公告)日： 1989-02-21
- 发明人: Jean Wagnon , Claude Plouzane , Bernard Tonnerre , Dino Nisato
- 申请人： Jean Wagnon , Claude Plouzane , Bernard Tonnerre , Dino Nisato
- 申请人地址： FRX Paris
- 专利权人： Societe Anonyme: Sanofi
- 当前专利权人： Societe Anonyme: Sanofi
- 当前专利权人地址： FRX Paris
- 优先权： FRX8609680 19860703
- 主分类号： C07D209/14
- IPC分类号： C07D209/14 ; C07D209/16 ; C07D413/06 ; C07B53/00 ; C07D403/12 ; C07D405/12
摘要：
The present invention relates to a process for the stereo-specific synthesis of indole derivatives of formula: ##STR1## which consists in using 3-tosyloxy-1,2-O-isopropylidenepropane-1,2-diol (II) in an optically pure form in order to introduce the asymetric carbon C* of compound (I). Compound (II) is condensed with a suitable primary amine in order to prepare an oxazolidinone and condensation with a suitable phenol, and the oxazolidinone ring is then opened to form an indole compound (I).
公开/授权文献
- USD393807S Watch and strap 公开/授权日：1998-04-28
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