发明授权
- 专利标题: 6-Oxo-trans-octa- and decahydroquinolines
- 专利标题(中): 6-氧代 - 反 - 八 - 和十氢喹啉
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申请号: US874741申请日: 1986-06-16
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公开(公告)号: US4826986A公开(公告)日: 1989-05-02
- 发明人: Diane L. Huser , John M. Schaus
- 申请人: Diane L. Huser , John M. Schaus
- 申请人地址: IN Indianapolis
- 专利权人: Eli Lilly and Company
- 当前专利权人: Eli Lilly and Company
- 当前专利权人地址: IN Indianapolis
- 主分类号: A61K31/435
- IPC分类号: A61K31/435 ; A61K31/4745 ; A61K31/505 ; A61K31/517 ; A61P9/12 ; A61P15/14 ; A61P25/00 ; A61P25/28 ; C07D215/20 ; C07D215/22 ; C07D215/233 ; C07D215/42 ; C07D215/54 ; C07D215/56 ; C07D471/04 ; C07D491/10 ; C07D498/04 ; C07D513/04
摘要:
7- or 8-Substituted, partially hydrogenated pyrazolo[3,4-g]quinoline, thiazolo[4,5-g]quinoline, oxazolo[4,5-g]quinoline, and pyrrolo[3,4-g]quinoline derivatives, and 8- or 9-substituted, partially hydrogenated pyrido[2,3-g]quinazoline derivatives are D-2 dopamine agonists. 6-Oxo-1-substituted-octahydroquinolines and 6-oxo-1-substituted-decahydroquinolines which are additionally substituted in the 3- or 4-position are intermediates useful in preparation of the dopamine agonists. Acetals of 4,6-dioxo-1-substituted-decahydroquinoline 3-carboxylic acid esters enable synthesis of the foregoing compounds.
公开/授权文献
- US5971546A Image display device 公开/授权日:1999-10-26
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