发明授权
US4851518A Di and tri-O-acetyl-"O-iso-valeryl-23-O-demycinosyl tylosins, hydrazone
derivatives thereof and processes for their preparation
失效
二和三-O-乙酰基-O-异戊酰基-23-O-脱霉素基泰乐菌素，其腙衍生物及其制备方法
- 专利标题： Di and tri-O-acetyl-"O-iso-valeryl-23-O-demycinosyl tylosins, hydrazone derivatives thereof and processes for their preparation
- 专利标题（中）： 二和三-O-乙酰基-O-异戊酰基-23-O-脱霉素基泰乐菌素，其腙衍生物及其制备方法
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申请号： US812148申请日： 1985-12-23
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公开(公告)号： US4851518A公开(公告)日： 1989-07-25
- 发明人: Alan K. Mallams , Randall R. Rossman
- 申请人： Alan K. Mallams , Randall R. Rossman
- 申请人地址： NJ Kenilworth
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： NJ Kenilworth
- 主分类号： C07H17/08
- IPC分类号： C07H17/08
摘要：
There are disclosed novel di- and tri-O-acetyl-23-O-demycinosyl-4"-O-iso-valeryltylosins and the pharmaceutically acceptable salts thereof, which have improved activity as antibacterials and provide higher blood levels than other tylosin derived compounds. These compounds have the following structural formula ##STR1## wherein R is acetyl or hydrogen and z is for example O or ##STR2##Processes for selectively deacylating the 2' and 4"-positions of 3,2',4",4'"-tetra-O-acyltylosin or 2',4",4'"-tri-O-acyltylosin and for the selective acylation of 2',4"-di-O-acyltylosin and 2',4",4'"-tri-O-acyltylosin are also disclosed.
公开/授权文献
- USPP10507P Begonia plant named `Deli` 公开/授权日：1998-07-14
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