发明授权
US4886877A Novel 2'-deoxy-5-substituted uridine derivatives, processes for
preparing the same and antitumor agent containing the same
失效
新的2'-脱氧-5-取代的尿苷衍生物，其制备方法和含有它们的抗肿瘤剂
- 专利标题： Novel 2'-deoxy-5-substituted uridine derivatives, processes for preparing the same and antitumor agent containing the same
- 专利标题（中）： 新的2'-脱氧-5-取代的尿苷衍生物，其制备方法和含有它们的抗肿瘤剂
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申请号： US163237申请日： 1988-02-26
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公开(公告)号： US4886877A公开(公告)日： 1989-12-12
- 发明人: Setsuro Fujii , Jun-ichi Yamashita , Hiroshi Matsumoto , Setsuo Takeda , Tadafumi Terada , Mitsugi Yasumoto , Norio Unemi
- 申请人： Setsuro Fujii , Jun-ichi Yamashita , Hiroshi Matsumoto , Setsuo Takeda , Tadafumi Terada , Mitsugi Yasumoto , Norio Unemi
- 申请人地址： JPX Tokyo
- 专利权人： Taiho Pharmaceutical Company Limited
- 当前专利权人： Taiho Pharmaceutical Company Limited
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX58-91190 19830523; JPX58-170149 19830914; JPX58-170147 19830914
- 主分类号： C07D405/04
- IPC分类号： C07D405/04 ; C07H19/06
摘要：
Novel 2'-deoxy-5-substituted uridine derivative represented by the general formula, ##STR1## wherein R.sub.1 is a hydrogen atom, a benzoyl group or a tetrahydrofuranyl group; R.sub.2 is a fluorine atom or a trifluoromethyl group; and any one of R.sub.3 and R.sub.4 is a hydrogen atom and the other one is an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a benzyl group having as the substituents selected from the group consisting of a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms and a nitro group, or an alkyl group having 1 to 3 carbon atoms having one or two phenyl groups as the substituents.The novel 2'-deoxy-5-substituteduridine derivative possesses excellent antitumor activity with less toxicity, thus it is useful as antitumor agent.
公开/授权文献
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