发明授权
US4916147A 3-[(4-Aroyl) phenoxy (or phenylthio)]-cyclopentanecarboxylic acid
analogues and treatment of cerebral edema therewith
失效
3 - [（4-芳酰基）苯氧基（或苯硫基）] - 环戊烷羧酸类似物，并用其治疗脑水肿
- 专利标题： 3-[(4-Aroyl) phenoxy (or phenylthio)]-cyclopentanecarboxylic acid analogues and treatment of cerebral edema therewith
- 专利标题（中）： 3 - [（4-芳酰基）苯氧基（或苯硫基）] - 环戊烷羧酸类似物，并用其治疗脑水肿
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申请号： US887772申请日： 1986-06-21
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公开(公告)号： US4916147A公开(公告)日： 1990-04-10
- 发明人: Katsuhiro Imaki , Tadao Okegawa , Yoshinobu Arai
- 申请人： Katsuhiro Imaki , Tadao Okegawa , Yoshinobu Arai
- 申请人地址： JPX Osaka
- 专利权人： Ono Pharmaceutical Co., Ltd.
- 当前专利权人： Ono Pharmaceutical Co., Ltd.
- 当前专利权人地址： JPX Osaka
- 优先权： JPX60-157990 19850719
- 主分类号： C07C62/08
- IPC分类号： C07C62/08 ; A61K31/19 ; A61K31/195 ; A61K31/215 ; A61K31/34 ; A61K31/341 ; A61K31/38 ; A61K31/381 ; A61K31/41 ; A61P3/00 ; A61P7/10 ; A61P43/00 ; C07C45/29 ; C07C45/46 ; C07C45/67 ; C07C49/84 ; C07C51/00 ; C07C51/09 ; C07C62/38 ; C07C67/00 ; C07C69/757 ; C07C201/00 ; C07C205/45 ; C07C231/00 ; C07C231/12 ; C07C235/46 ; C07C235/66 ; C07C313/00 ; C07C323/61 ; C07D257/04 ; C07D307/46 ; C07D333/16 ; C07D333/22 ; C07D333/56
摘要：
Novel compounds of the general formula: ##STR1## [wherein X represents an oxygen atom or sulfur atom, R.sup.1, R.sup.2 and R.sup.3 represent a hydrogen atom, a halogen atom or an alkyl group of from 1 to 4 carbon atom(s) independently or a formula: R.sup.3' ##STR2## (wherein R.sup.3' represents a hydrogen atom or an alkyl group of from 1 to 4 carbon(s))in place of a formula: ##STR3## R.sup.4 represents a general formula: ##STR4## or --N(R.sup.9).sub.2 (in which W represents an oxygen atom or sulfur atom, R.sup.6, R.sup.7 and R.sup.8 represent a hydrogen atom, a halogen atom, a nitro group, an alkyl group of from 1 to 4 carbon atom(s), a hydroxy group or an alkoxy group of from 1 to 4 carbon atom(s) independently, each of R.sup.9 represents a hydrogen atom, an alkyl group of from 1 to 4 carbon atom(s) or a phenyl group and Y represents a single bond or an alkylene group or an alkenylene group of from 1 to 4 carbon atom(s).), and R.sup.5 represents a 5-tetrazolyl group or a general formula: --COOR.sup.10 (in which R.sup.10 represents a hydrogen atom or an alkyl group of from 1 to 4 carbon atom(s))]and non-toxic salts possess inhibitory effect on cerebral edema.
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