发明授权
US4945064A Estrane and androstane derivatives, process for producing them and
preparations containing these compounds
失效
雌激素和雄甾烷衍生物，其制备方法和含有这些化合物的制剂
- 专利标题： Estrane and androstane derivatives, process for producing them and preparations containing these compounds
- 专利标题（中）： 雌激素和雄甾烷衍生物，其制备方法和含有这些化合物的制剂
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申请号： US147580申请日： 1988-01-19
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公开(公告)号： US4945064A公开(公告)日： 1990-07-31
- 发明人: Helmut Hofmeister , Henry Laurent , Paul E. Schulze , Klaus Annen , Rudolf Wiechert , Kunhard Pollow , Bernhard Manz , Hans-Joerg Grill
- 申请人： Helmut Hofmeister , Henry Laurent , Paul E. Schulze , Klaus Annen , Rudolf Wiechert , Kunhard Pollow , Bernhard Manz , Hans-Joerg Grill
- 申请人地址： DEX Berlin and Bergkamen
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： DEX Berlin and Bergkamen
- 优先权： DEX3337179 19831010
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; C07F7/22 ; C07J1/00 ; C07J7/00 ; C07J13/00 ; C07J21/00 ; C07J51/00 ; C07J53/00 ; C07J63/00 ; C07J71/00
摘要：
Estrane and androstane derivatives of formula I ##STR1## wherein X is bromine, iodine, triphenyltin or trialkyltin of 1 to 6 carbon atoms per alkyl radical,Y represents two hydrogen atoms or methylene,Z represents two hydrogen atoms, oxo or alkylenedioxy of 2 to 6 carbon atoms andV is ethylene, vinylene, 1,3-propylene or cyclopropylene,R.sub.1 is hydrogen or a hydrocarbon radical of up to 8 hydrocarbon atoms, optionally interrupted by an oxa group or substituted by an oxo group,R.sub.2 is methyl or ethyl,R.sub.3 and R.sub.4 represent a carbon-carbon bond or R.sub.3 is hydrogen and R.sub.4 is hydrogen or methyl,.DELTA.symbolizes a 4(5)-double bond if Z signifies two hydrogen atoms or an oxo group; or a 5(6)-double bond or, for the estrane derivatives of formula I, also a 5(10)-double bond, if Z is alkylenedioxy,are pharmacologically effective substances or intermediates for preparation thereof.