发明授权
- 专利标题: Benzodiazepine analogs
- 专利标题(中): 苯二氮卓类似物
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申请号: US316463申请日: 1989-02-27
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公开(公告)号: US4957915A公开(公告)日: 1990-09-18
- 发明人: Sun H. Kim , John E. Taylor
- 申请人: Sun H. Kim , John E. Taylor
- 申请人地址: MA Hopkinton
- 专利权人: Biomeasure, Inc.
- 当前专利权人: Biomeasure, Inc.
- 当前专利权人地址: MA Hopkinton
- 主分类号: C07D243/14
- IPC分类号: C07D243/14 ; A61K31/55 ; A61K31/551 ; A61P25/28 ; A61P25/30 ; C07D243/16 ; C07D243/18 ; C07D243/20 ; C07D243/24 ; C07D401/12 ; C07D403/12 ; C07D405/12 ; C07D413/12
摘要:
BZDs of the general formula 1: ##STR1## where: R represents H, alkyl, alkenyl, cycloalkyl or cycloalkenyl each with up to 8 carbon atoms, phenylalkyl with an alkylene chain of 1 to 3 carbon atoms and optionally substituted on the phenyl radical with one or two substituents selected from the group consisting of Cl, Br, F, CN, CF.sub.3, NO.sub.2, lower alkyl, and OCH.sub.3, or represents a phenyl radical which is optionally substituted with one or two substituents selected from the group consisting of Cl, F, Br, CN, I, CF.sub.3 NO.sub.2, lower alkyl and OCH.sub.3, or represents a 5-membered or 6-membered heterocyclic radical with 1 or 2 heteroatoms from the group consisting of O, N and S; R.sub.1 represents H or, together with R.sub.2, forms a bond; R.sub.2 and R.sub.4 independently of one another represent H, or an alkyl radical with 1 to 6 carbon atoms, or represent a phenylalkyl radical with an alkyl chain of 1 to 3 carbon atoms and optionally substituted on the phenyl radical with one or two substituents selected from the group consisting of Cl, Br, F, CN, CF.sub.3, NO.sub.2, CH.sub.3, C.sub.2 H.sub.5 and OCH.sub.3, or R.sub.2 together with R.sub.1, forms a bond; R.sub.3 is (CH.sub.2).sub.n CH or (CH.sub.2).sub.n --CR.sub.14 .dbd.CR.sub.14, where n is between 0 and 5 inclusive and R.sub.14 .dbd.HOL a bond; R.sub.5 and R.sub.6 independently of one another represent H, Cl, F, Br, NO.sub.2, CN, CF.sub.3, lower alkyl, or OCH.sub.3 ; R.sub.7 and R.sub.9 are independently CH.sub.2 or C.dbd.0; R.sub.8 is ##STR2## where p and q are independently between 0 and 4 and the sum of p and q is 4 or less; and R.sub.11 and R.sub.12 are independently H or a lower alkyl of between 1 and 5 carbon atoms.
公开/授权文献
- US5552727A Digital phase locked loop circuit 公开/授权日:1996-09-03
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