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34 条记录 (耗时 0.027 秒)

    Automobile
    7.
    外观设计
    Automobile 失效

    公开(公告)号：USD296537S

    公开(公告)日：1988-07-05

    申请号：US750266

    申请日：1985-07-01

    申请人： Sun H. Kim

    设计人： Sun H. Kim

    Antiulcer compounds
    8.
    发明授权
    Antiulcer compounds 失效
    抗溃疡化合物

    公开(公告)号：US4598067A

    公开(公告)日：1986-07-01

    申请号：US661354

    申请日：1984-10-16

    申请人： Sun H. Kim

    发明人： Sun H. Kim

    IPC分类号： C07D487/04 ,  A61K31/415 ,  A61K31/47 ,  A61K31/472 ,  A61K38/00 ,  A61P1/04 ,  C07C67/00 ,  C07C231/00 ,  C07C237/12 ,  C07D207/28 ,  C07D217/16 ,  C07D217/26 ,  C07D233/64 ,  C07D403/12 ,  C07D471/04 ,  C07K5/06 ,  C07K5/078 ,  A61K37/43 ,  C07K5/08

    CPC分类号： C07D403/12 ,  C07D207/28 ,  C07D471/04 ,  C07K5/06026 ,  C07K5/06173 ,  A61K38/00

    摘要： A compound having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein A is N--Ac--Sar, pGlu, or homo-pGlu-; B is an aryl group, a heteroaryl group, a cycloalkyl group, an aralkyl group, a heteroalkyl group, a heteroaralkyl group, a benzoyl group, an alkyl group, an acetyl group, or a substituted aryl group wherein the substituent is halogen, hydroxy, alkoxy, nitro, cyano, or hydroxyalkyl; E is H or an alkyl group; B and E being separate substituents or, together with C.sub.1 and the nitrogen atom to which B is attached, forming a 5,6, or 7-membered ring; m is an integer between 0 and 4; either F is ##STR2## wherein R is an alkoxy group or an aralkoxy group; or F is ##STR3## and is capable of forming a 6-membered ring with the nitrogen atom of A, provided that F can only be ##STR4## forming a ring with A when A is pGlu or homo-pGlu.

    摘要翻译： 具有式“IMAGE”的化合物或其药学上可接受的盐，其中A是N-Ac-Sar，pGlu或homo-pGlu-; B是芳基，杂芳基，环烷基，芳烷基，杂烷基，杂芳烷基，苯甲酰基，烷基，乙酰基或取代的芳基，其中取代基是卤素，羟基 ，烷氧基，硝基，氰基或羟基烷基; E是H或烷基; B和E是独立的取代基，或者与C1和与B连接的氮原子一起形成5,6或7-元环; m是0和4之间的整数; F是F，其中R是烷氧基或芳烷氧基; 或者F是，并且能够与A的氮原子形成6元环，条件是当A是pGlu或homo-pGlu时，F只能与A形成环。

    Imidazole compounds which reduce gastric acid secretion
    9.
    发明授权
    Imidazole compounds which reduce gastric acid secretion 失效
    减少胃酸分泌的咪唑化合物

    公开(公告)号：US4495193A

    公开(公告)日：1985-01-22

    申请号：US454733

    申请日：1982-12-30

    申请人： Sun H. Kim ,  Jacques-Pierre Moreau

    发明人： Sun H. Kim ,  Jacques-Pierre Moreau

    IPC分类号： C07D209/46 ,  C07D403/06 ,  C07D403/12 ,  A61K31/415

    CPC分类号： C07D403/06 ,  C07D209/46 ,  C07D403/12

    摘要： A compound having gastric acid secretion reducing activity and having the formula ##STR1## wherein each V and W, independently, is H, --CH.sub.2 COOR.sup.4 where R.sup.4 is H or lower alkyl, --CH.sub.2 CN, or ##STR2## or V and W together represent .dbd.CHCOOR.sup.4 or .dbd.CHCN; A is ##STR3## R.sup.1 is H or CH.sub.3 ; L is CH.sub.2 S; Q is O or CH.sub.2 S; n is 0 or 1; 2 m 4; each R.sup.2 and R.sup.3, independently, is hydrogen, lower alkyl, lower cycloalkyl, or lower aralkyl; or R.sup.2 and R.sup.3, together with the nitrogen atom to which they are attached, form a 4, 5, or 6 membered heterocyclic ring containing 0, 1, or 2 oxygen atoms and 1, 2, or 3 nitrogen atoms and being unsubstituted or lower alkyl substituted; and Ar is a single ring aromatic group selected from aryl, substituted aryl, fused aryl, or heteroaryl; or the pharmaceutically acceptable salt thereof.

    摘要翻译： 具有胃酸分泌降低活性并具有下式的化合物：其中每个V和W独立地是H，-CH 2 COOR 4，其中R 4是H或低级烷基，-CH 2 CN或V和W一起代表= CHCOOR4或= CHCN; A是 + TR R1是H或CH3; L是CH2S; Q是O或CH2S; n为0或1; 2 m 4; 每个R 2和R 3独立地是氢，低级烷基，低级环烷基或低级芳烷基; 或R 2和R 3与它们所连接的氮原子一起形成含有0,1或2个氧原子和1,2或3个氮原子的4,5或6元杂环，并且是未取代的或低级的 烷基取代; Ar为选自芳基，取代芳基，稠合芳基或杂芳基的单环芳基; 或其药学上可接受的盐。