发明授权
- 专利标题: Extended shelf life platelet preparations and process for preparing the same
- 专利标题(中): 延长保质期血小板制剂及其制备方法
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申请号: US255621申请日: 1988-10-07
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公开(公告)号: US4994367A公开(公告)日: 1991-02-19
- 发明人: Arthur P. Bode , William A. L. Heaton , Stein Holme , David T. Miller
- 申请人: Arthur P. Bode , William A. L. Heaton , Stein Holme , David T. Miller
- 申请人地址: NC Greenville
- 专利权人: East Carolina University
- 当前专利权人: East Carolina University
- 当前专利权人地址: NC Greenville
- 主分类号: A01N1/02
- IPC分类号: A01N1/02
摘要:
A first aspect of the present invention is a blood platelet preparation comprising blood platelets, an adenylate cyclase stimulator, a phosphodiesterase inhibitor, a thrombin inhibitor, and a plasmin inhibitor. A second aspect of the present invention is a plasma-free platelet storage medium containing dextrose, sodium citrate, sodium bicarbonate, and a platelet activation inhibitor, with a preferred platelet activation inhibitor comprising an adenylate cyclase stimulator in combination with a phosphodiesterase inhibitor. A third aspect of the present invention is a process for producing a plasma-free platelet preparation comprising producing platelet-rich plasma (PRP) from whole blood, adding a platelet activation inhibitor thereto, centrifuging the PRP to deposit the platelets on the bottom of the centrifuge container, removing the platelet-free plasma supernatant therefrom and adding a plasma-free liquid platelet storage medium thereto. A preferred platelet activation inhibitor for the process comprises an adenylate cyclase stimulator in combination with a phosphodiesterase inhibitor.A preferred adenylate cyclase stimulator is Prostaglandin El, a preferred phosphodiesterase inhibitor is Theophylline, a preferred plasmin inhibitor is Aprotinin, and a preferred thrombin inhibitor is N-(2-naphthylsulfonylglycyl)-D,L-amidinophenylalaninpiperidide.
公开/授权文献
- US5448675A Telecommunications distribution frame with tracing 公开/授权日:1995-09-05