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    Extended shelf life platelet preparations and process for preparing the same
    1.
    发明授权
    Extended shelf life platelet preparations and process for preparing the same 失效
    延长保质期血小板制剂及其制备方法

    公开(公告)号：US4994367A

    公开(公告)日：1991-02-19

    申请号：US255621

    申请日：1988-10-07

    申请人： Arthur P. Bode ,  William A. L. Heaton ,  Stein Holme ,  David T. Miller

    发明人： Arthur P. Bode ,  William A. L. Heaton ,  Stein Holme ,  David T. Miller

    IPC分类号： A01N1/02

    CPC分类号： A01N1/02 ,  A01N1/0226

    摘要： A first aspect of the present invention is a blood platelet preparation comprising blood platelets, an adenylate cyclase stimulator, a phosphodiesterase inhibitor, a thrombin inhibitor, and a plasmin inhibitor. A second aspect of the present invention is a plasma-free platelet storage medium containing dextrose, sodium citrate, sodium bicarbonate, and a platelet activation inhibitor, with a preferred platelet activation inhibitor comprising an adenylate cyclase stimulator in combination with a phosphodiesterase inhibitor. A third aspect of the present invention is a process for producing a plasma-free platelet preparation comprising producing platelet-rich plasma (PRP) from whole blood, adding a platelet activation inhibitor thereto, centrifuging the PRP to deposit the platelets on the bottom of the centrifuge container, removing the platelet-free plasma supernatant therefrom and adding a plasma-free liquid platelet storage medium thereto. A preferred platelet activation inhibitor for the process comprises an adenylate cyclase stimulator in combination with a phosphodiesterase inhibitor.A preferred adenylate cyclase stimulator is Prostaglandin El, a preferred phosphodiesterase inhibitor is Theophylline, a preferred plasmin inhibitor is Aprotinin, and a preferred thrombin inhibitor is N-(2-naphthylsulfonylglycyl)-D,L-amidinophenylalaninpiperidide.

    摘要翻译： 本发明的第一方面是包含血小板，腺苷酸环化酶刺激剂，磷酸二酯酶抑制剂，凝血酶抑制剂和纤溶酶抑制剂的血小板制剂。 本发明的第二方面是含有葡萄糖，柠檬酸钠，碳酸氢钠和血小板活化抑制剂的无血浆血小板储存培养基，其中优选的血小板活化抑制剂包含与磷酸二酯酶抑制剂组合的腺苷酸环化酶刺激剂。 本发明的第三方面是一种生产无血浆血小板制剂的方法，其包括从全血制备富含血小板的血浆（PRP），向其中加入血小板活化抑制剂，离心PRP以将血小板沉积在 离心容器，从其中除去不含血小板的血浆上清液，并向其中加入无血浆的血小板储存培养基。 用于该方法的优选的血小板活化抑制剂包括与磷酸二酯酶抑制剂组合的腺苷酸环化酶刺激剂。 优选的腺苷酸环化酶刺激剂是前列腺素E1，优选的磷酸二酯酶抑制剂是茶碱，优选的纤溶酶抑制剂是抑肽酶，优选的凝血酶抑制剂是N-（2-萘磺酰基甘氨酰）-D，L-脒基苯丙氨酸哌啶。

    Fixed-dried red blood cells
    2.
    发明授权
    Fixed-dried red blood cells 失效
    固定干红细胞

    公开(公告)号：US07358039B2

    公开(公告)日：2008-04-15

    申请号：US11041560

    申请日：2005-01-24

    申请人： Thomas H. Fischer ,  Marjorie S. Read ,  Arthur P. Bode ,  Timothy C. Nichols

    发明人： Thomas H. Fischer ,  Marjorie S. Read ,  Arthur P. Bode ,  Timothy C. Nichols

    IPC分类号： A01N1/02 ,  A01N63/00

    CPC分类号： A01N1/0226 ,  A01N1/02 ,  A01N1/0284 ,  A01N1/0289 ,  A61K35/18

    摘要： Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenicity to platelets, and have oblated blood group antigens. The RBCs are preferably fixed by means of cross-linkers with aldehyde functions such as paraformaldehyde or glutaraldehyde either alone or in combination. Native oxygen kinetics are achieved by preparing the red blood cells with 1,6-diphosphofructose. Blood group antigens and chemical functions that render the lyophilized RBCs thrombogenic are occluded by chemically attaching polyoxyethylene glycol polymers to the surface membrane of the red blood cells. The cross-linked red blood cells are preferably died by lyophilization.

    摘要翻译： 公开了固定干红细胞（RBC）及其制备方法。 红细胞在用蒸馏水或适当的缓冲液重构后，与氧化天然亲和力结合，具有部分变形能力，对血小板具有最小的血栓形成，并且具有扁平的血型抗原。 RBCs优选通过具有醛官能团的交联剂例如多聚甲醛或戊二醛单独或组合固定。 通过制备具有1,6-二磷酸果糖的红细胞来实现天然氧动力学。 通过将聚氧乙烯二醇聚合物化学连接到红细胞的表面膜上，使冻干的RBC血栓形成的血型抗原和化学功能被阻断。 交联的红细胞优选通过冻干死亡。

    Method for the microbial decontamination of blood platelets
    3.
    发明授权
    Method for the microbial decontamination of blood platelets 失效
    血小板微生物去污方法

    公开(公告)号：US5891393A

    公开(公告)日：1999-04-06

    申请号：US945395

    申请日：1997-09-12

    申请人： Marjorie S. Read ,  Arthur P. Bode ,  Louis J. Summaria

    发明人： Marjorie S. Read ,  Arthur P. Bode ,  Louis J. Summaria

    IPC分类号： A61L2/00 ,  A61L9/00

    CPC分类号： A61L2/0088

    摘要： A method for inactivating microbiological contaminants in a human blood platelet preparation is disclosed. The method comprises, first, providing blood platelets, particularly human blood platelets, suspected of being contaminated with microorganisms. The platelets are then contacted to a fixative for a time sufficient to fix the platelets. After fixing, the platelets are preferably washed and dried to produce fixed-dried platelets. The step of contacting the platelets to a fixative is carried out for a time sufficient to kill some or all the of the contaminating microorganisms.

    摘要翻译： PCT No.PCT / US96 / 05018 Sec。 371日期：1997年9月12日 102（e）日期1997年9月12日PCT 1996年4月9日PCT PCT。 公开号WO96 / 32969 日期：1996年10月24日公开了人血小板制剂中微生物污染物失活的方法。 该方法首先提供怀疑被微生物污染的血小板，特别是人血小板。 然后将血小板与固定剂接触足以固定血小板的时间。 固定后，优选洗涤和干燥血小板以产生固定干燥的血小板。 使血小板与固定剂接触的步骤进行足够时间来杀死部分或全部污染微生物。

    Fixed dried red blood cells and method of use
    4.
    发明授权
    Fixed dried red blood cells and method of use 失效
    固定干红细胞和使用方法

    公开(公告)号：US06884573B2

    公开(公告)日：2005-04-26

    申请号：US10231635

    申请日：2002-08-30

    申请人： Thomas H. Fischer ,  Marjorie S. Read ,  Arthur P. Bode ,  Timothy C. Nichols

    发明人： Thomas H. Fischer ,  Marjorie S. Read ,  Arthur P. Bode ,  Timothy C. Nichols

    IPC分类号： A01N1/02 ,  A61K35/18 ,  A01N63/00

    CPC分类号： A01N1/0226 ,  A01N1/02 ,  A01N1/0284 ,  A01N1/0289 ,  A61K35/18

    摘要： Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenicity to platelets, and have oblated blood group antigens. The RBCs are preferably fixed by means of cross-linkers with aldehyde functions such as paraformaldehyde or glutaraldehyde either alone or in combination. Native oxygen kinetics are achieved by preparing the red blood cells with 1,6-diphosphofructose. Blood group antigens and chemical functions that render the lyophilized RBCs thrombogenic are occluded by chemically attaching polyoxyethylene glycol polymers to the surface membrane of the red blood cells. The cross-linked red blood cells are preferably died by lyophilization.

    摘要翻译： 公开了固定干红细胞（RBC）及其制备方法。 红细胞在用蒸馏水或适当的缓冲液重构后，与氧化天然亲和力结合，具有部分变形能力，对血小板具有最小的血栓形成，并且具有扁平的血型抗原。 RBCs优选通过具有醛官能团的交联剂例如多聚甲醛或戊二醛单独或组合固定。 通过制备具有1,6-二磷酸果糖的红细胞来实现天然氧动力学。 通过将聚氧乙烯二醇聚合物化学连接到红细胞的表面膜上，使冻干的RBC血栓形成的血型抗原和化学功能被阻断。 交联的红细胞优选通过冻干死亡。