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1.发明授权
公开(公告)号：US4994367A
公开(公告)日：1991-02-19
申请号：US255621
申请日：1988-10-07
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0226
摘要： A first aspect of the present invention is a blood platelet preparation comprising blood platelets, an adenylate cyclase stimulator, a phosphodiesterase inhibitor, a thrombin inhibitor, and a plasmin inhibitor. A second aspect of the present invention is a plasma-free platelet storage medium containing dextrose, sodium citrate, sodium bicarbonate, and a platelet activation inhibitor, with a preferred platelet activation inhibitor comprising an adenylate cyclase stimulator in combination with a phosphodiesterase inhibitor. A third aspect of the present invention is a process for producing a plasma-free platelet preparation comprising producing platelet-rich plasma (PRP) from whole blood, adding a platelet activation inhibitor thereto, centrifuging the PRP to deposit the platelets on the bottom of the centrifuge container, removing the platelet-free plasma supernatant therefrom and adding a plasma-free liquid platelet storage medium thereto. A preferred platelet activation inhibitor for the process comprises an adenylate cyclase stimulator in combination with a phosphodiesterase inhibitor.A preferred adenylate cyclase stimulator is Prostaglandin El, a preferred phosphodiesterase inhibitor is Theophylline, a preferred plasmin inhibitor is Aprotinin, and a preferred thrombin inhibitor is N-(2-naphthylsulfonylglycyl)-D,L-amidinophenylalaninpiperidide.
摘要翻译： 本发明的第一方面是包含血小板，腺苷酸环化酶刺激剂，磷酸二酯酶抑制剂，凝血酶抑制剂和纤溶酶抑制剂的血小板制剂。 本发明的第二方面是含有葡萄糖，柠檬酸钠，碳酸氢钠和血小板活化抑制剂的无血浆血小板储存培养基，其中优选的血小板活化抑制剂包含与磷酸二酯酶抑制剂组合的腺苷酸环化酶刺激剂。 本发明的第三方面是一种生产无血浆血小板制剂的方法，其包括从全血制备富含血小板的血浆（PRP），向其中加入血小板活化抑制剂，离心PRP以将血小板沉积在 离心容器，从其中除去不含血小板的血浆上清液，并向其中加入无血浆的血小板储存培养基。 用于该方法的优选的血小板活化抑制剂包括与磷酸二酯酶抑制剂组合的腺苷酸环化酶刺激剂。 优选的腺苷酸环化酶刺激剂是前列腺素E1，优选的磷酸二酯酶抑制剂是茶碱，优选的纤溶酶抑制剂是抑肽酶，优选的凝血酶抑制剂是N-（2-萘磺酰基甘氨酰）-D，L-脒基苯丙氨酸哌啶。
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2.发明授权Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets 失效用于红细胞和血小板的合成，无血浆，可输送的储存培养基
公开(公告)号：US5487971A
公开(公告)日：1996-01-30
申请号：US128066
申请日：1993-09-28
申请人： Stein Holme , William A. L. Heaton
发明人： Stein Holme , William A. L. Heaton
CPC分类号： A01N1/0226 , A01N1/02 , A61K35/16 , G01N33/96 , G01N2496/80 , G01N33/66 , G01N33/80
摘要： The invention is a sterile, plasma-free storage medium for blood components including red blood cells and for platelets processed separately or together. The red cell storage medium includes adenine and a physiologically compatible, aqueous electrolyte solution. In one liter of this electrolyte solution there is between about 3.0 grams and about 25.0 grams of dextrose, between about 3.0 grams and about 6.0 grams of sodium citrate, and between about 2.0 grams and about 4.2 grams of sodium bicarbonate. The red cell storage medium is isotonic and has a pH in a range of between about 6.8 and about 7.4. The red cell storage medium is capable of storing and preserving red cells for at least 49 days.
摘要翻译： 本发明是用于血液成分的无菌，无血浆的储存培养基，包括红细胞和单独或一起加工的血小板。 红细胞储存培养基包括腺嘌呤和生理相容的含水电解质溶液。 在1升这种电解质溶液中，存在约3.0克和约25.0克葡萄糖之间，约3.0克至约6.0克柠檬酸钠和约2.0克至约4.2克碳酸氢钠之间。 红细胞储存培养基是等渗的并且pH在约6.8和约7.4之间的范围内。 红细胞储存培养基能够储存和保存红细胞至少49天。
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3.发明授权Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets 失效用于红细胞和血小板的合成，无血浆，可输送的储存培养基
公开(公告)号：US4961928A
公开(公告)日：1990-10-09
申请号：US99012
申请日：1987-09-21
申请人： Stein Holme , William A. L. Heaton
发明人： Stein Holme , William A. L. Heaton
CPC分类号： A01N1/02 , A01N1/0226 , A61K35/18 , G01N33/96 , G01N2496/80 , G01N33/66 , G01N33/80
摘要： The invention is a sterile, plasma-free storage medium for blood components including red blood cells and for platelets processed separately or together. The red cell storage medium includes a physiologically compatible, aqueous electrolyte solution. In one liter of this electrolyte solution there is between about 3.0 grams and about 25.0 grams of dextrose, between about 3.0 grams and about 6.0 grams of sodium citrate, and between about 2.0 grams and about 4.2 grams of sodium bicarbonate. The red cell storage medium is isotonic and has a pH in a range of between about 6.8 and about 7.4. The red cell storage medium is capable of storing and preserving red cells for at least 49 days. The medium can also contain adenine.
摘要翻译： 本发明是用于血液成分的无菌，无血浆的储存培养基，包括红细胞和单独或一起加工的血小板。 红细胞储存介质包括生理相容的含水电解质溶液。 在1升这种电解质溶液中，存在约3.0克和约25.0克葡萄糖之间，约3.0克至约6.0克柠檬酸钠和约2.0克至约4.2克碳酸氢钠之间。 红细胞储存培养基是等渗的并且pH在约6.8和约7.4之间的范围内。 红细胞储存培养基能够储存和保存红细胞至少49天。 培养基还可以含有腺嘌呤。
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4.发明授权Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets 失效用于红细胞和血小板的合成，无血浆，可输送的储存培养基
公开(公告)号：US5248506A
公开(公告)日：1993-09-28
申请号：US593932
申请日：1990-10-05
申请人： Stein Holme , William A. L. Heaton
发明人： Stein Holme , William A. L. Heaton
CPC分类号： A01N1/0226 , A01N1/02 , A61K35/16 , G01N33/96 , G01N2496/80 , G01N33/66 , G01N33/80
摘要： The invention is a sterile, plasma-free storage medium for blood components including red blood cells and for platelets processed separately or together. The red cell storage medium includes a physiologically compatible, aqueous electrolyte solution. In one liter of this electrolyte solution there is between about 3.0 grams and about 25.0 grams of dextrose, between about 3.0 grams and about 6.0 grams of sodium citrate, and between about 2.0 grams and about 4.2 grams of sodium bicarbonate. The red cell storage medium is isotonic and has a pH in a range of between about 6.8 and about 7.4. The red cell storage medium is capable of storing and preserving red cells for at least 49 days.
摘要翻译： 本发明是用于血液成分的无菌，无血浆的储存培养基，包括红细胞和单独或一起加工的血小板。 红细胞储存介质包括生理相容的含水电解质溶液。 在1升这种电解质溶液中，存在约3.0克和约25.0克葡萄糖之间，约3.0克至约6.0克柠檬酸钠和约2.0克至约4.2克碳酸氢钠之间。 红细胞储存培养基是等渗的并且pH在约6.8和约7.4之间的范围内。 红细胞储存培养基能够储存和保存红细胞至少49天。
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