Invention Grant
- Patent Title: Hepatocyte growth factor
- Patent Title (中): 肝细胞生长因子
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Application No.: US58211Application Date: 1987-06-04
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Publication No.: US5004805APublication Date: 1991-04-02
- Inventor: Eiichi Gohda , Hirohito Tsubouchi , Hiroyuki Nakayama , Shuichi Hirono , Kozo Takahashi , Shuji Hashimoto , Yasushi Daikuhara
- Applicant: Eiichi Gohda , Hirohito Tsubouchi , Hiroyuki Nakayama , Shuichi Hirono , Kozo Takahashi , Shuji Hashimoto , Yasushi Daikuhara
- Applicant Address: JPX Kagoshima JPX Kagoshima JPX Kagoshima JPX Kagoshima JPX Tokyo
- Assignee: Hashimoto; Shuji,Daikuhara; Yasushi,Gohda; Eiichi,Tsubouchi; Hirohito,Mitsubishi Kasei Corporation
- Current Assignee: Hashimoto; Shuji,Daikuhara; Yasushi,Gohda; Eiichi,Tsubouchi; Hirohito,Mitsubishi Kasei Corporation
- Current Assignee Address: JPX Kagoshima JPX Kagoshima JPX Kagoshima JPX Kagoshima JPX Tokyo
- Priority: JPX61-166495 19860714
- Main IPC: A61K38/22
- IPC: A61K38/22 ; A61K35/16 ; A61K38/00 ; A61P1/16 ; C07K14/475
Abstract:
A hepatocyte growth factor comprising a proteinous substance derived from human blood and showing the following physicochemical properties and physiologic activity:(i) its molecular weight is estimated to be approximately 76,000 to 92,00 by SDS-PAGE analysis (under non-reductive conditon);(ii) it possesses HGF activity;(iii) the HGF activity is inactivated by heat treatment for 10 minutes at 80.degree. C.;(iv) the HGF activity may be lost by digestion with trypsin or with chymotrypsin; and(v) it has a high affinity for heparin.
Public/Granted literature
- US6076596A Cooling apparatus for high-temperature medium by boiling and condensing refrigerant Public/Granted day:2000-06-20
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