发明授权
- 专利标题: Asymmetric synthesis of furo(3,4-c) pyridine derivatives
- 专利标题(中): 呋喃(3,4-c)吡啶衍生物的不对称合成
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申请号: US557975申请日: 1990-07-26
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公开(公告)号: US5043448A公开(公告)日: 1991-08-27
- 发明人: Charles Eck
- 申请人: Charles Eck
- 申请人地址: FRX
- 专利权人: Societe de Conseils de Recherches et d'Applications Scientifiques
- 当前专利权人: Societe de Conseils de Recherches et d'Applications Scientifiques
- 当前专利权人地址: FRX
- 优先权: GBX8917168 19890727
- 主分类号: B01J27/02
- IPC分类号: B01J27/02 ; B01J27/06 ; B01J31/04 ; C07B53/00 ; C07B61/00 ; C07D491/04 ; C07D491/048 ; C07D491/056
摘要:
The invention relates to a method for the preparation of a non-racemic furo [3,4-c] pyridine derivatives of the formula I ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 stand for various substitutents, comprising adding a concentrated strong acid to a solution of a non-racemic compound of the formula II ##STR2## in an amount sufficient to catalyze a deprotection/cyclodehydration. These compounds are known antihypertensives.