发明授权
US5071988A Substituted benzoylbenzene-, biphenyl- and 2-oxazole-alkanoic acid
derivatives
失效
取代的苯甲酰基苯，联苯基和2-恶唑烷酸衍生物
- 专利标题： Substituted benzoylbenzene-, biphenyl- and 2-oxazole-alkanoic acid derivatives
- 专利标题（中）： 取代的苯甲酰基苯，联苯基和2-恶唑烷酸衍生物
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申请号： US661734申请日： 1991-02-27
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公开(公告)号： US5071988A公开(公告)日： 1991-12-10
- 发明人: Amedeo A. Failli , Anthony F. Kreft, III , John H. Musser , Annette L. Banker , James A. Nelson , Uresh S. Shah
- 申请人： Amedeo A. Failli , Anthony F. Kreft, III , John H. Musser , Annette L. Banker , James A. Nelson , Uresh S. Shah
- 申请人地址： NY New York
- 专利权人： American Home Products Corporation
- 当前专利权人： American Home Products Corporation
- 当前专利权人地址： NY New York
- 主分类号： C07C45/00
- IPC分类号： C07C45/00 ; C07C45/63 ; C07C45/72 ; C07C59/90 ; C07C69/738 ; C07C205/45 ; C07C255/40 ; C07D215/14 ; C07D263/32 ; C07D413/12
摘要：
There are disclosed compounds of the formulaA(CH.sub.2).sub.n O--BwhereinA is ##STR1## n is 1-2; B is ##STR2## wherein R.sup.4 and R.sup.5 are each, independently, hydrogen or lower alkyl;R.sup.6 is hydrogen, halo or nitro; ##STR3## R.sup.8 is lower alkyl; m is 0-3;and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated nasobronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.
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