利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.016 秒)

    3,4-dihydro-2H-benzo[1,4]oxazine derivatives
    3.
    发明授权
    3,4-dihydro-2H-benzo[1,4]oxazine derivatives 失效
    3,4-二氢-2H-苯并[1,4]恶嗪衍生物

    公开(公告)号：US06221863B1

    公开(公告)日：2001-04-24

    申请号：US09475383

    申请日：1999-12-30

    申请人： Richard E. Mewshaw ,  Uresh S. Shah

    发明人： Richard E. Mewshaw ,  Uresh S. Shah

    IPC分类号： A61K31538

    CPC分类号： C07D413/14 ,  A61K31/538

    摘要： Compounds are provided having the following formula: wherein: R1 is hydrogen or halogen; R2 is hydrogen, alkoxy or carboximide; R3 is hydrogen, alkyl, alkylaryl, aryl or substituted aryl; R4 is hydrogen, CN, halogen, or carboximide; and X is CH or N; or pharmaceutically acceptable salts thereof.

    摘要翻译： 提供具有下式的化合物：其中：R 1是氢或卤素; R 2是氢，烷氧基或甲酰亚胺; R 3是氢，烷基，烷基芳基，芳基或取代的芳基; R 4是氢，CN，卤素或甲酰亚胺; 且X为CH或N; 或其药学上可接受的盐。

    Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
    5.
    发明授权
    Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase 失效
    取代的吲哚，茚，吡喃吲哚和四氢咔唑 - 链烷酸衍生物作为PLA2和脂氧合酶的抑制剂

    公开(公告)号：US5229516A

    公开(公告)日：1993-07-20

    申请号：US911434

    申请日：1992-07-10

    申请人： John H. Musser ,  Anthony F. Kreft, III ,  Amedeo A. Failli ,  Christopher A. Demerson ,  Uresh S. Shah ,  James A. Nelson

    发明人： John H. Musser ,  Anthony F. Kreft, III ,  Amedeo A. Failli ,  Christopher A. Demerson ,  Uresh S. Shah ,  James A. Nelson

    IPC分类号： C07C323/62 ,  C07D209/22 ,  C07D215/14 ,  C07D401/12 ,  C07D401/14 ,  C07D417/12 ,  C07D491/04

    CPC分类号： C07D401/12 ,  C07C323/62 ,  C07D209/22 ,  C07D215/14 ,  C07D401/14 ,  C07D417/12 ,  C07D491/04

    摘要： There are disclosed compounds of the formulaA(CH.sub.2).sub.n O-BwhereinA is C.sub.4 -C.sub.8 alkyl, phenoxyethyl, phenoxyphenyl or a group having the formula ##STR1## wherein ##STR2## R.sup.1 is hydrogen, lower alkyl, phenyl or phenyl substituted with trifluoromethyl;R.sup.2 is hydrogen or lower alkyl; orR.sup.1 and R.sup.2 taken together form a benzene ring;R.sup.3 is hydrogen or lower alkyl;n is 1-2;B is ##STR3## wherein ##STR4## m is 0-3; R.sup.5 is ##STR5## or phenyl or phenyl substituted by halo, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl;R.sup.6 is A(CH.sub.2).sub.n O-- or halo; with the proviso that when R.sup.6 is halo, R.sup.5 is ##STR6## R.sup.7 is lower alkyl; Y is --CH.sub.2 -- or --O--;R.sup.8 is lower alkyl or --(CH.sub.2).sub.m CO.sub.2 R.sup.3 ;R.sup.9 is ##STR7## or --CH.sub.2 R.sup.10 ; R.sup.10 is lower alkyl, phenyl, phenyl substituted with carboxy, halo, loweralkylthio or loweralkylsulfinyl, pyridyl, furanyl or quinolinyl;R.sup.11 is lower alkyl or phenyl;Z is hydrogen, lower alkyl or --N(CH.sub.3)OH;and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.

    摘要翻译： 公开了式A（CH 2）n O-B的化合物，其中A是C 4 -C 8烷基，苯氧基乙基，苯氧基苯基或具有下式的基团：其中R 1是氢，低级烷基 ，苯基或被三氟甲基取代的苯基; R2是氢或低级烷基; 或R 1和R 2一起形成苯环; R3是氢或低级烷基; n为1-2; B是 其中 m是0-3; R 5为苯基或被卤素，低级烷硫基，低级烷基亚磺酰基或低级烷基磺酰基取代的苯基; R6是A（CH2）nO-或卤素; 条件是当R 6为卤素时，R 5为低级烷基; Y是-CH 2 - 或-O-; R8是低级烷基或 - （CH2）mCO2R3; R9是或-CH2R10; R 10为低级烷基，苯基，被羧基，卤素，低级烷硫基或低级烷基亚磺酰基取代的苯基，吡啶基，呋喃基或喹啉基; R11为低级烷基或苯基; Z是氢，低级烷基或-N（CH 3）OH; 及其药理学上可接受的盐及其在治疗炎性病症如类风湿性关节炎，溃疡性结肠炎，牛皮癣和其他立即超敏反应中的用途; 治疗白三烯介导的鼻支气管阻塞性通气条件，如过敏性鼻炎，过敏性支气管哮喘等; 和作为胃细胞保护剂。