发明授权
US5087561A Humoral hypercalcemic factor antagonists modified at position 13 by
biotin
失效
通过生物素在13位修饰的体液高钙因子拮抗剂
- 专利标题： Humoral hypercalcemic factor antagonists modified at position 13 by biotin
- 专利标题（中）： 通过生物素在13位修饰的体液高钙因子拮抗剂
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申请号： US545256申请日： 1990-06-28
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公开(公告)号： US5087561A公开(公告)日： 1992-02-11
- 发明人: Michael Rosenblatt , Michael Chorev , Eliahu Roubini , Ruth F. Nutt , Le T. Duong
- 申请人： Michael Rosenblatt , Michael Chorev , Eliahu Roubini , Ruth F. Nutt , Le T. Duong
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： C07K14/575
- IPC分类号： C07K14/575 ; G01N33/74
摘要：
The present invention relates to the use of peptide analogues as inhibitors of their respective naturally occurring peptides. The structure of the peptide hormone analogues is exemplified by human humoral hypercalcemic factor (hHCF), wherein Lys.sup.13 or Lys.sup.11 is modified on the epsilon-amino group by biotin so as to produce HCF analogues which can inhibit the action of HCF.