发明授权
US5096897A Antithrombotic substituted cycloalkano(b)dihydroindole- and
-indole-sulphonamides
失效
抗生素替代环孢素(B)二氢吲哚并 - 亚磺酰胺
- 专利标题: Antithrombotic substituted cycloalkano(b)dihydroindole- and -indole-sulphonamides
- 专利标题(中): 抗生素替代环孢素(B)二氢吲哚并 - 亚磺酰胺
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申请号: US678563申请日: 1991-03-28
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公开(公告)号: US5096897A公开(公告)日: 1992-03-17
- 发明人: Horst Boshagen , Ulrich Muller , Ulrich Rosentreter , Erwin Bischoff , Volker-Bernd Fiedler , Elisabeth Perzborn , Joachim Hutter , Peter Norman , Nigel J. Cuthbert , Hilary P. Francis , Marie G. McKenniff
- 申请人: Horst Boshagen , Ulrich Muller , Ulrich Rosentreter , Erwin Bischoff , Volker-Bernd Fiedler , Elisabeth Perzborn , Joachim Hutter , Peter Norman , Nigel J. Cuthbert , Hilary P. Francis , Marie G. McKenniff
- 申请人地址: DEX Leverkusen
- 专利权人: Bayer Aktiengesellschaft
- 当前专利权人: Bayer Aktiengesellschaft
- 当前专利权人地址: DEX Leverkusen
- 优先权: GBX8924392 19891030
- 主分类号: C07D209/86
- IPC分类号: C07D209/86 ; A61K31/40 ; A61K31/403 ; A61P7/02 ; A61P9/08 ; A61P9/10 ; A61P11/00 ; A61P37/08 ; C07D209/88 ; C07D209/94
摘要:
Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X is aryl, alkyl or CF.sub.3,m and Z each is 1, 2, 3 or 4,n is 0, 1 or 2,A is a bond or --NH--, andY is OH, alkoxy, aryloxy, amino or sulphonylamine, with the proviso that, in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group,or a salt thereof.
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