发明授权
- 专利标题： Polypeptides useful as blockers of calcium channels
- 专利标题（中）： 多数作为钙通道阻塞剂有用
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申请号： US415139申请日： 1989-09-29
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公开(公告)号： US5122596A公开(公告)日： 1992-06-16
- 发明人: Douglas Phillips , Nicholas A. Saccomano , Robert A. Volkmann
- 申请人： Douglas Phillips , Nicholas A. Saccomano , Robert A. Volkmann
- 申请人地址： NY New York
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 当前专利权人地址： NY New York
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A01N37/44 ; A01N63/02 ; A61K38/17 ; A61P1/00 ; A61P3/00 ; A61P3/14 ; A61P9/00 ; A61P9/06 ; A61P9/08 ; A61P9/12 ; A61P13/02 ; A61P15/00 ; A61P25/00 ; A61P43/00 ; C07K1/20 ; C07K2/00 ; C07K4/00 ; C07K14/435
摘要：
This invention relates to a polypeptide found to be present in the venom of the Agelenopsis aperta spider and to polypeptides having substantially the same amino acid sequence and substantially the same activity as said polypeptide. The polypeptides of this invention and the salts thereof block calcium channels in cells of various organisms and are useful in blocking said calcium channels in cells, per se; in the treatment of calcium channel mediated diseases and conditions; and in the control of invertebrate pests. This invention also relates to compositions comprising said polypeptides and salts thereof.
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