发明授权
US5190871A Use of the site-specific integrating function of phage .phi.C31
失效
使用噬菌体（PHI）C31的基因特异性整合功能
- 专利标题： Use of the site-specific integrating function of phage .phi.C31
- 专利标题（中）： 使用噬菌体（PHI）C31的基因特异性整合功能
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申请号： US364959申请日： 1989-06-12
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公开(公告)号： US5190871A公开(公告)日： 1993-03-02
- 发明人: Karen L. Cox , Stuart A. Kuhstoss , R. Nagaraja Rao , Mark A. Richardson , Brigitte E. Schoner , Eugene T. Seno
- 申请人： Karen L. Cox , Stuart A. Kuhstoss , R. Nagaraja Rao , Mark A. Richardson , Brigitte E. Schoner , Eugene T. Seno
- 申请人地址： IN Indianapolis
- 专利权人： Eli Lilly and Company
- 当前专利权人： Eli Lilly and Company
- 当前专利权人地址： IN Indianapolis
- 主分类号： C12N1/21
- IPC分类号： C12N1/21 ; C12N9/10 ; C12N15/11 ; C12N15/52 ; C12N15/76 ; C12N15/90 ; C12P19/62 ; C12R1/465
摘要：
The present invention provides a method for transforming an actinomycete with an integrating vector which has the advantages of high transformation rates into a broad host range, site-specific integration, and stable maintenance without antibiotic selection. Also provided are methods for the increased production of antibiotics and for the production of hybrid antibiotics.
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