发明授权
- 专利标题： CD-4/cytotoxic gene fusions
- 专利标题（中）： CD-4 /细胞毒性基因融合
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申请号： US223270申请日： 1988-07-22
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公开(公告)号： US5206353A公开(公告)日： 1993-04-27
- 发明人: Edward A. Berger , Bernard Moss , Thomas R. Fuerst , Ira Pastan , David Fitzgerald , Tamio Mizukami , Vijay K. Chaudhary
- 申请人： Edward A. Berger , Bernard Moss , Thomas R. Fuerst , Ira Pastan , David Fitzgerald , Tamio Mizukami , Vijay K. Chaudhary
- 申请人地址： DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： DC Washington
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K14/21 ; C07K14/73 ; C07K16/00
摘要：
A chimeric gene directing the synthesis of hybrid recombinant fusion protein in a suitable expression vector has been constructed. The fusion protein possesses the property of selective cytotoxicity against specific virus-infected cells. A CD4(178)-PE40 hybrid fusion protein has been made for selectively killing HIV-infected cells.
公开/授权文献
- US5421739A One-piece bridge for connecting modular units 公开/授权日：1995-06-06
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