发明授权
- 专利标题： Regioselective chemical modification of monoclonal antibodies
- 专利标题（中）： 单克隆抗体的区域选择性化学修饰
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申请号： US613127申请日： 1990-11-14
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公开(公告)号： US5208008A公开(公告)日： 1993-05-04
- 发明人: Girish Ranadive , Howard S. Rosenzweig , Michael Epperly , William Bloomer
- 申请人： Girish Ranadive , Howard S. Rosenzweig , Michael Epperly , William Bloomer
- 申请人地址： PA Pittsburgh
- 专利权人： University of Pittsburgh
- 当前专利权人： University of Pittsburgh
- 当前专利权人地址： PA Pittsburgh
- 主分类号： C07K1/00
- IPC分类号： C07K1/00 ; C07K1/107 ; C07K16/00
摘要：
A method of selectively modifying an immunoglobulin having at least one Fab region and at least one Fc region, each region having an isoelectric point wherein said isoelectric point of the Fab fragment of said immunoglobulin is different than the isoelectric point of the Fc fragment of the immunoglobulin, said method comprising modification of the immunoglobulin at a pH between the respective isoelectric points of the Fab and Fc fragments of the immunoglobulin.
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