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公开(公告)号：US5208008A
公开(公告)日：1993-05-04
申请号：US613127
申请日：1990-11-14
CPC分类号： C07K1/1077 , C07K1/003 , C07K16/00
摘要： A method of selectively modifying an immunoglobulin having at least one Fab region and at least one Fc region, each region having an isoelectric point wherein said isoelectric point of the Fab fragment of said immunoglobulin is different than the isoelectric point of the Fc fragment of the immunoglobulin, said method comprising modification of the immunoglobulin at a pH between the respective isoelectric points of the Fab and Fc fragments of the immunoglobulin.
摘要翻译： 选择性修饰具有至少一个Fab区和至少一个Fc区的免疫球蛋白的方法，每个区具有等电点，其中所述免疫球蛋白的Fab片段的所述等电点不同于免疫球蛋白的Fc片段的等电点 所述方法包括在Fab的各个等电点和免疫球蛋白的Fc片段之间的pH下修饰免疫球蛋白。
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公开(公告)号：US07201481B2
公开(公告)日：2007-04-10
申请号：US10470651
申请日：2003-07-09
IPC分类号： G02C7/02
CPC分类号： G02B1/043 , C08F220/56 , C08F230/08 , Y10S525/937 , C08L43/04 , C08L83/04
摘要： This invention is directed to ophthalmic materials and ophthalmic lenses that are a co-polymerization product of a (a) hydrophilic monomer with (b) a tris(siloxy)silyl group-containing monomer, (c) a wide variety of hydrophobic monomers (both aliphatic and aromatic) and usually a (d) polyfluorinated monomer, as well as optional monomers or monomer mixtures that can include a cationic monomer, a non-aromatic hydrophobic monomer and a poly(dimethylsiloxy)silyl group-containing monomer. A contact lens prepared from such a co-polymer exhibits enhanced water content, while maintaining exceptional oxygen permeability, thereby providing a lens that can be worn comfortably for prolonged periods of time. A process for the preparation of such lenses is also disclosed.
摘要翻译： 本发明涉及作为（a）亲水性单体与（b）含三（甲硅烷氧基）甲硅烷基的单体的共聚合产物的眼科材料和眼用透镜，（c）各种各样的疏水性单体 脂族和芳族的）和通常的（d）多氟化单体，以及可以包括阳离子单体，非芳族疏水单体和含聚（二甲基甲硅烷氧基）甲硅烷基的单体的任选的单体或单体混合物。 由这种共聚物制备的隐形眼镜表现出增强的含水量，同时保持卓越的氧气渗透性，从而提供可以在较长时间内舒适佩戴的镜片。 还公开了制备这种透镜的方法。
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公开(公告)号：US06649722B2
公开(公告)日：2003-11-18
申请号：US09731331
申请日：2000-12-06
IPC分类号： G02C704
CPC分类号： G02B1/043 , C08F220/56 , C08F230/08 , Y10S525/937 , C08L43/04 , C08L83/04
摘要： This invention is directed to ophthalmic materials and ophthalmic lenses that are a co-polymerization product of a (a) hydrophilic monomer with (b) a tris(siloxy)silyl group-containing monomer, (c) a wide variety of hydrophobic monomers (both aliphatic and aromatic) and usually a (d) polyfluorinated monomer, as well as optional monomers or monomer mixtures that can include a cationic monomer, a non-aromatic hydrophobic monomer and a poly(dimethylsiloxy)silyl group-containing monomer. A contact lens prepared from such a co-polymer exhibits enhanced water content, while maintaining exceptional oxygen permeability, thereby providing a lens that can be worn comfortably for prolonged periods of time. A process for the preparation of such lenses is also disclosed.
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