发明授权
- 专利标题： Antimicrobial amphiphilic peptides
- 专利标题（中）： 抗微生物活性肽
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申请号： US686116申请日： 1991-04-15
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公开(公告)号： US5225399A公开(公告)日： 1993-07-06
- 发明人: Michael Zasloff , W. Lee Maloy , U. Prasad Kari , Michael Brasseur
- 申请人： Michael Zasloff , W. Lee Maloy , U. Prasad Kari , Michael Brasseur
- 申请人地址： PA Philadelphia
- 专利权人： The Children's Hospital of Philadelphia
- 当前专利权人： The Children's Hospital of Philadelphia
- 当前专利权人地址： PA Philadelphia
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61P31/04 ; A61P31/10 ; A61P31/12 ; A61P35/00 ; C07K7/08
摘要：
A biologically active peptide which includes the following structure:R.sub.1 -R.sub.1 -R.sub.1 -R.sub.4 -R.sub.1 -R.sub.1 -R.sub.2 -R.sub.1 -R.sub.1 -R.sub.1 -R.sub.1 -R.sub.1 -R.sub.1 -R.sub.1a -R.sub.1 -R.sub.1 -R.sub.3 -R.sub.2 R.sub.2 -R.sub.1aR.sub.1 and R.sub.1a are hydrophobic amino acids, R.sub.2 is a basic hydrophilic amino acid, R.sub.3 is a neutral hydrophilic amino acid, and R.sub.4 is hydrophobic or basic hydrophilic amino acid. Preferably, R.sub.1a is cysteine.Examples of peptides have the following structural formulae:(SEQ ID NO:1);(SEQ ID NO:2);(SEQ ID NO:3);(SEQ ID NO:4);(SEQ ID NO:5); and(SEQ ID NO:6).The peptide may be employed in a pharmaceutical composition.
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