发明授权
US5227399A Pyranylphenyl naphthalene lactones as inhibitors of leukotriene
biosynthesis
失效
苯吡喃基萘内酯作为白三烯生物合成的抑制剂
- 专利标题： Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis
- 专利标题（中）： 苯吡喃基萘内酯作为白三烯生物合成的抑制剂
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申请号： US966213申请日： 1992-10-26
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公开(公告)号： US5227399A公开(公告)日： 1993-07-13
- 发明人: Robert N. Young , Yves Girard , John W. Gillard , Laird A. Trimble , John Scheigetz , James A. Yergey , Yves Ducharme , Deborah A. Nicoll-Griffith , John H. Hutchinson
- 申请人： Robert N. Young , Yves Girard , John W. Gillard , Laird A. Trimble , John Scheigetz , James A. Yergey , Yves Ducharme , Deborah A. Nicoll-Griffith , John H. Hutchinson
- 申请人地址： CAX Kirkland
- 专利权人： Merck Frosst Canada, Inc.
- 当前专利权人： Merck Frosst Canada, Inc.
- 当前专利权人地址： CAX Kirkland
- 主分类号： C07D307/92
- IPC分类号： C07D307/92 ; C07D407/12 ; C07D409/12 ; C07D493/08
摘要：
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis and allograft rejection and in preventing the formation of atherosclerotic plaques.
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