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US5254466A Site-specific modification of the candida tropicals genome 失效
念珠菌热带基因组的位点特异性修饰

Site-specific modification of the candida tropicals genome
摘要:
The POX genes of C. tropicalis are disrupted resulting in the complete blockage of the beta-oxidation pathway in the strain. Fermentation of C. tropicalis cells having disrupted genes on alkane, fatty acid and fatty acid ester substrates produces substantially pure dicarboxylic acids in substantially quantitative yield.
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