Invention Grant
- Patent Title: Compositions containing biguanides and derivatives thereof as inhibitors of nonenzymatic cross-linking
- Patent Title (中): 含有双胍类及其衍生物作为非酶交联抑制剂的组合物
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Application No.: US807609Application Date: 1991-12-16
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Publication No.: US5254593APublication Date: 1993-10-19
- Inventor: Peter C. Ulrich , Anthony Cerami
- Applicant: Peter C. Ulrich , Anthony Cerami
- Applicant Address: NY New York
- Assignee: The Rockefeller University
- Current Assignee: The Rockefeller University
- Current Assignee Address: NY New York
- Main IPC: A61K8/43
- IPC: A61K8/43 ; A61K31/155 ; A61K31/195 ; A61K31/40 ; A61K31/415 ; A61K31/4178 ; A61K31/44 ; A61K31/445 ; A61K31/495 ; A61K31/535 ; A61K31/55 ; A61K38/19 ; A61K38/20 ; A61K38/21 ; A61K38/38 ; A61K39/00 ; A61Q11/00 ; A61Q19/08 ; C07D405/14 ; C07K16/28 ; G01N33/533 ; G01N33/573 ; G01N33/58 ; G01N33/68
Abstract:
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
Public/Granted literature
- US4687258A Remote control system for a locomotive Public/Granted day:1987-08-18
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