发明授权
US5258389A O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
失效
O-芳基，O-烷基，O-链烯基和O-炔基雷帕霉素衍生物
- 专利标题： O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
- 专利标题（中）： O-芳基，O-烷基，O-链烯基和O-炔基雷帕霉素衍生物
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申请号： US973807申请日： 1992-11-09
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公开(公告)号： US5258389A公开(公告)日： 1993-11-02
- 发明人: Mark Goulet , William H. Parsons , Peter J. Sinclair , Frederick Wong , Matthew J. Wyvratt
- 申请人： Mark Goulet , William H. Parsons , Peter J. Sinclair , Frederick Wong , Matthew J. Wyvratt
- 申请人地址： NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： NJ Rahway
- 主分类号： C07D498/18
- IPC分类号： C07D498/18 ; A61K31/395 ; C07D498/16
摘要：
O-Aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-42 and/or C-31. These compounds are useful in a mammalian host for the treatment of autoimmune diseases and diseases of inflammation, infectious diseases, the prevention of rejection of foreign organ transplants and the treatment of solid tumors.
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