发明授权
- 专利标题： Dipeptide derivatives
- 专利标题（中）： 二肽衍生物
-
申请号： US974211申请日： 1992-11-10
-
公开(公告)号： US5272268A公开(公告)日： 1993-12-21
- 发明人: Tatsuo Toyoda , Toshihiro Fujioka , Kunio Hayashi , Masuhisa Nakamura , Naofumi Hashimoto
- 申请人： Tatsuo Toyoda , Toshihiro Fujioka , Kunio Hayashi , Masuhisa Nakamura , Naofumi Hashimoto
- 申请人地址： JPX Osaka
- 专利权人： Shionogi & Co., Ltd.
- 当前专利权人： Shionogi & Co., Ltd.
- 当前专利权人地址： JPX Osaka
- 优先权： JPX2-172050 19900628
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07D213/56 ; C07D233/54 ; C07D263/06 ; C07D277/30 ; C07D277/46 ; C07D295/26 ; C07D401/12 ; C07D405/12 ; C07D413/06 ; C07D417/06 ; C07D417/12 ; C07K5/02 ; C07K5/065 ; C07D401/06 ; C07D249/14 ; C07D277/18
摘要：
A following dipeptide derivative of the following formula (I) is provided, which is capable of inhibiting the enzymatic activity of renin and thereby depressing the renin-angiotensin system and lowering the blood pressure. ##STR1## wherein: R.sup.1 is C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.10 cycloalkyl, aryl, or heterocyclic radical;R.sup.2 is carbamoyl, aryl, 5- or 6-membered heterocyclic radical, C.sub.1 -C.sub.12 alkyl-S--, C.sub.1 -C.sub.12 alkyl-S--CH.sub.2 --, or C.sub.3 -C.sub.10 cycloalkyl-S--;R.sup.3 is aryl or 5- or 6-membered heterocyclic radical;R.sup.4 is R.sup.4' --SO.sub.2 or R.sup.4' --CO;R.sup.4' is aryl, C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl; C.sub.3 -C.sub.10 cycloaklyl, or heterocyclic radical;X is CH.sub.2, NH, O, or S; andY is CO or NHSO.sub.2, wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4' each may be substituted with one to three substituents.
信息查询
IPC分类:
