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公开(公告)号：US5223615A
公开(公告)日：1993-06-29
申请号：US974212
申请日：1992-11-10
IPC分类号： A61K38/00 , C07D213/56 , C07D233/54 , C07D263/06 , C07D277/30 , C07D277/46 , C07D295/26 , C07D401/12 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07K5/02 , C07K5/065
CPC分类号： C07D233/64 , C07D213/56 , C07D263/06 , C07D277/30 , C07D277/46 , C07D295/26 , C07D401/12 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07K5/0205 , C07K5/06078 , A61K38/00
摘要： A dipeptide derivative of the formula (I) is provided, which is capable of inhibiting the enzymatic activity of renin and thereby depressing the renin-angiotensin system and lowering the blood pressure, provided. ##STR1## wherein: R.sup.1 is C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.10 cycloalkyl, aryl, or heterocyclic radical;R.sup.2 is carbamoyl, aryl, 5- or 6-membered heterocyclic radical, C.sub.1 -C.sub.12 alkyl-S--, C.sub.1 -C.sub.12 alkyl-S--CH.sub.2 -, or C.sub.3 -C.sub.10 cycloalkyl-S-;R.sup.3 is aryl or 5- or 6-membered heterocyclic radical;R.sup.4 is R.sup.4' --SO.sub.2 or R.sup.4' --CO;R.sup.4' is aryl, C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl; C.sub.3 -C.sub.10 cycloalkyl, or heterocyclic radical;X is CH.sub.2, NH, O, or S; andY is CO or NHSO.sub.2, wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4' each may be substituted with one to three substituents.
摘要翻译： 提供式（I）的二肽衍生物，其能够抑制肾素的酶活性，从而抑制肾素 - 血管紧张素系统并降低血压。 （I）其中：R1是C1-C12烷基，C2-C6烯基，C2-C6炔基，C3-C10环烷基，芳基或杂环基; R2是氨基甲酰基，芳基，5-或6-元杂环基，C1-C12烷基-S-，C1-C12烷基-S-CH2-或C3-C10环烷基-S-; R3是芳基或5-或6-元杂环基; R4是R4'-SO2或R4'-CO; R 4'是芳基，C 1 -C 12烷基，C 2 -C 6烯基，C 2 -C 6炔基; C3-C10环烷基或杂环基; X是CH 2，NH，O或S; 并且Y是CO或NHSO 2，其中R 1，R 2，R 3和R 4'各自可被一至三个取代基取代。
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公开(公告)号：US07962016B2
公开(公告)日：2011-06-14
申请号：US10652493
申请日：2003-09-02
申请人： Yun Soo Choe , Ok Keun Song , Hyung Min Kim , Takashi Ujihara , Takeo Wakimoto , Naofumi Hashimoto
发明人： Yun Soo Choe , Ok Keun Song , Hyung Min Kim , Takashi Ujihara , Takeo Wakimoto , Naofumi Hashimoto
CPC分类号： C23C14/243
摘要： Provided is a heating crucible for an organic thin film forming apparatus, the heating crucible including a main body in which to contain an organic substance, a cover provided on the main body, the cover formed of an insulating material and having a nozzle through which a gaseous organic substance comes out from the main body, a cover heater formed as a thin film type on the top surface of the cover, and a body heater heating the main body.
摘要翻译： 本发明提供一种用于有机薄膜形成装置的加热坩埚，所述加热坩埚包括主体，其中容纳有机物质，设置在主体上的盖，由绝缘材料形成的盖，并具有喷嘴， 气体有机物质从主体出来，在盖的顶表面上形成为薄膜型的盖加热器和加热主体的主体加热器。
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公开(公告)号：US5272268A
公开(公告)日：1993-12-21
申请号：US974211
申请日：1992-11-10
IPC分类号： A61K38/00 , C07D213/56 , C07D233/54 , C07D263/06 , C07D277/30 , C07D277/46 , C07D295/26 , C07D401/12 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07K5/02 , C07K5/065 , C07D401/06 , C07D249/14 , C07D277/18
CPC分类号： C07D233/64 , C07D213/56 , C07D263/06 , C07D277/30 , C07D277/46 , C07D295/26 , C07D401/12 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07K5/0205 , C07K5/06078 , A61K38/00
摘要： A following dipeptide derivative of the following formula (I) is provided, which is capable of inhibiting the enzymatic activity of renin and thereby depressing the renin-angiotensin system and lowering the blood pressure. ##STR1## wherein: R.sup.1 is C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.10 cycloalkyl, aryl, or heterocyclic radical;R.sup.2 is carbamoyl, aryl, 5- or 6-membered heterocyclic radical, C.sub.1 -C.sub.12 alkyl-S--, C.sub.1 -C.sub.12 alkyl-S--CH.sub.2 --, or C.sub.3 -C.sub.10 cycloalkyl-S--;R.sup.3 is aryl or 5- or 6-membered heterocyclic radical;R.sup.4 is R.sup.4' --SO.sub.2 or R.sup.4' --CO;R.sup.4' is aryl, C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl; C.sub.3 -C.sub.10 cycloaklyl, or heterocyclic radical;X is CH.sub.2, NH, O, or S; andY is CO or NHSO.sub.2, wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4' each may be substituted with one to three substituents.
摘要翻译： 提供下述式（I）的二肽衍生物，其能够抑制肾素的酶活性，从而抑制肾素 - 血管紧张素系统并降低血压。 （I）其中：R1是C1-C12烷基，C2-C6烯基，C2-C6炔基，C3-C10环烷基，芳基或杂环基; R2是氨基甲酰基，芳基，5-或6-元杂环基，C1-C12烷基-S-，C1-C12烷基-S-CH2-或C3-C10环烷基-S-; R3是芳基或5-或6-元杂环基; R4是R4'-SO2或R4'-CO; R 4'是芳基，C 1 -C 12烷基，C 2 -C 6烯基，C 2 -C 6炔基; C 3 -C 10环烷基或杂环基; X是CH 2，NH，O或S; 并且Y是CO或NHSO 2，其中R 1，R 2，R 3和R 4'各自可被一至三个取代基取代。
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公开(公告)号：US5194608A
公开(公告)日：1993-03-16
申请号：US719492
申请日：1991-06-24
IPC分类号： A61K38/00 , C07D213/56 , C07D233/54 , C07D233/64 , C07D263/06 , C07D277/30 , C07D277/46 , C07D277/56 , C07D295/26 , C07D401/12 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07K5/02 , C07K5/065
CPC分类号： C07D233/64 , C07D213/56 , C07D263/06 , C07D277/30 , C07D277/46 , C07D295/26 , C07D401/12 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07K5/0205 , C07K5/06078 , A61K38/00
摘要： A dipeptide derivative of formula (I) is provided, which is capable of inhibiting the enzymatic activity of renin and thereby depressing the renin-angiotensin system and lowering the blood pressure. ##STR1## wherein: R.sup.1 is C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.10 cycloalkyl, aryl, or heterocyclic radical;R.sup.2 is carbamoyl, aryl, 5- or 6-membered heterocyclic radical, C.sub.1 -C.sub.12 alkyl-S--, C.sub.1 -C.sub.12 alkyl-S--CH.sub.2 --, or C.sub.3 -C.sub.10 cycloalkyl-S--;R.sup.3 is aryl or 5- or 6-membered heterocyclic radical;R.sup.4 is R.sup.4' --SO.sub.2 or R.sup.4' --CO;R.sup.4' is aryl, C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl; C.sub.3 -C.sub.10 cycloalkyl, or heterocyclic radical;X is CH.sub.2, NH, O, or S; andY is CO or NHSO.sub.2, wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4' each may be substituted with one to three substituents.
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