Invention Grant
US5279946A Process for the preparation of
N-benzyloxycarbonyl-alpha-L-aspartyl-L-phenylalanine methyl ester
失效
制备N-苄氧羰基-α-L-天冬氨酰-L-苯丙氨酸甲酯的方法
- Patent Title: Process for the preparation of N-benzyloxycarbonyl-alpha-L-aspartyl-L-phenylalanine methyl ester
- Patent Title (中): 制备N-苄氧羰基-α-L-天冬氨酰-L-苯丙氨酸甲酯的方法
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Application No.: US727696Application Date: 1991-07-10
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Publication No.: US5279946APublication Date: 1994-01-18
- Inventor: Chein-Shyong Su , Huey-Lin Chung , Wuen-Hsian Huang , Hsin Tsai
- Applicant: Chein-Shyong Su , Huey-Lin Chung , Wuen-Hsian Huang , Hsin Tsai
- Applicant Address: TWX Taipei
- Assignee: Development Center for Biotechnology
- Current Assignee: Development Center for Biotechnology
- Current Assignee Address: TWX Taipei
- Main IPC: C12P21/02
- IPC: C12P21/02 ; C07K5/072 ; C12N9/50
Abstract:
Disclosed is a process for the preparation of N-benzyloxycarbonyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester wherein a protease is used to catalyze the condensation reaction of N-benzyloxycarbonyl-L-aspartic acid with L-phenylalanine methyl ester in a system consisting of ethyl acetate, citrate buffer with the addition of glycerol as a dispersing agent.
Public/Granted literature
- US5864915A Toothbrush Public/Granted day:1999-02-02
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