公开(公告)号：US5279946A

公开(公告)日：1994-01-18

申请号：US727696

申请日：1991-07-10

Applicant: Chein-Shyong Su ,  Huey-Lin Chung ,  Wuen-Hsian Huang ,  Hsin Tsai

Inventor： Chein-Shyong Su ,  Huey-Lin Chung ,  Wuen-Hsian Huang ,  Hsin Tsai

IPC: C12P21/02 ,  C07K5/072 ,  C12N9/50

CPC classification number: C07K5/0613 ,  C12N9/50

Abstract: Disclosed is a process for the preparation of N-benzyloxycarbonyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester wherein a protease is used to catalyze the condensation reaction of N-benzyloxycarbonyl-L-aspartic acid with L-phenylalanine methyl ester in a system consisting of ethyl acetate, citrate buffer with the addition of glycerol as a dispersing agent.

Abstract translation: 公开了制备N-苄氧羰基-α-L-天冬氨酰基-L-苯丙氨酸甲酯的方法，其中使用蛋白酶催化N-苄氧羰基-L-天冬氨酸与L-苯丙氨酸甲酯的缩合反应 系统由乙酸乙酯，柠檬酸盐缓冲液组成，加入甘油作为分散剂。