发明授权
- 专利标题： Peptide compound and its preparation
- 专利标题（中）： 肽化合物及其制备
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申请号： US696701申请日： 1991-05-07
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公开(公告)号： US5284828A公开(公告)日： 1994-02-08
- 发明人: Keiji Hemmi , Masahiro Neya , Naoki Fukami , Masashi Hashimoto , Hirokazu Tanaka , Hatsuko Kayakiri
- 申请人： Keiji Hemmi , Masahiro Neya , Naoki Fukami , Masashi Hashimoto , Hirokazu Tanaka , Hatsuko Kayakiri
- 申请人地址： JPX Osaka
- 专利权人： Fujisawa Pharmaceutical Co. Ltd.
- 当前专利权人： Fujisawa Pharmaceutical Co. Ltd.
- 当前专利权人地址： JPX Osaka
- 优先权： JPX9010740 19900514; JPX9026254 19901203; JPX9104064 19910227
- 主分类号： A61K38/55
- IPC分类号： A61K38/55 ; A61K38/00 ; A61K38/06 ; C07K1/02 ; C07K1/113 ; C07K5/02 ; C07K5/06 ; C07K5/078 ; C07K5/08 ; C07K5/083 ; C07K5/103 ; A61K37/02
摘要：
Novel peptides of the formula (I") ##STR1## in which R.sup.1 is hydrogen or acyl,R.sup.2.sub.c is lower alkyl,R.sup.3.sub.c is optionally N-substituted indolylmethyl,R.sup.4 is hydrogen, lower alkyl, C.sub.6-10 ar(lower)alkyl, amino(lower)alkyl, protected amino (lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl or optionally substituted heterocyclic (lower)alkyl,R.sup.5 is carboxy, protected carboxy, carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.7 is hydrogen or lower alkyl, andA is --O--, --NH--, lower alkylamino or lower alkylene,or a pharmaceutically acceptable salt thereof are disclosed.Additionally, the preparation of such peptides is described. The peptides are used to treat endothelin mediated diseases such as hypertension.
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