发明授权
- 专利标题： Thyroid-derived chondrocyte-stimulating factor
- 专利标题（中）： 甲状腺来源的软骨细胞刺激因子
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申请号： US654965申请日： 1991-02-13
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公开(公告)号： US5284830A公开(公告)日： 1994-02-08
- 发明人: R. Lane Smith , Deryk G. Jones
- 申请人： R. Lane Smith , Deryk G. Jones
- 申请人地址： CA Stanford
- 专利权人： The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人： The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人地址： CA Stanford
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K38/22 ; A61K39/395 ; A61K47/48 ; A61L27/22 ; A61P43/00 ; C07K1/16 ; C07K1/30 ; C07K14/435 ; C07K14/51 ; C07K14/705 ; C07K16/00 ; C07K16/22 ; C12N5/06 ; C12P21/08 ; G01N33/53 ; A61K37/36 ; C07K3/02 ; C07K15/06
摘要：
Thyroid-derived chondrocyte stimulating factor (TDCSF) is a high molecular weight complex (greater than 500 kd) of proteinaceous subunits which can be at least partially dissociated into active portions by 8 M urea. TDCSF stimulates articular chondrocyte and synovial fibroblast growth under serum-free conditions. TDCSF is useful for the culture of chondrocytes and fibroblasts in vitro as a serum substitute; for developing cartilage implants in vitro; and for in vivo use in cartilage and bone defect repair and degenerative joint diseases. TDCSF is stabilized in the presence of reducing agents for disulfide bonds. Antibodies for and conjugates of TDCSF are also disclosed.
公开/授权文献
- USD287367S Motorized shovel 公开/授权日：1986-12-23
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