发明授权
- 专利标题： Derivatives of endogenous mediators, their salts, method of preparation, applications and compositions in which they are present
- 专利标题（中）： 内源介体的衍生物，其盐，制备方法，应用和组合物
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申请号： US699027申请日： 1991-05-13
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公开(公告)号： US5298491A公开(公告)日： 1994-03-29
- 发明人: Jacques Chauveau , Michel Delaage , Anne Morel , Louis Segu
- 申请人： Jacques Chauveau , Michel Delaage , Anne Morel , Louis Segu
- 申请人地址： FRX Marseille
- 专利权人： Immunotech
- 当前专利权人： Immunotech
- 当前专利权人地址： FRX Marseille
- 优先权： FRX9006292 19900515; FRX9101292 19910130
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K51/00 ; C07C213/06 ; C07C217/56 ; C07C235/04 ; C07C239/20 ; C07D209/14 ; C07D209/16 ; C07D233/24 ; C07K1/113 ; C07K5/06 ; C07K14/00 ; C07K16/00 ; G01N33/50 ; G01N33/78 ; A61K31/405 ; G01N21/75
摘要：
Derivatives of biologically active molecules containing a primary amine group and a hydroxylated nucleus, and their addition salts with mineral or organic acids, having general formula I:R'R"N--A--B--O--CH.sub.2 --CO--NH--R (I)A=linear or branched C.sub.1 -C.sub.5 alkylene;B=C.sub.4 -C.sub.10 aromatic nucleus with optional heteroatom, or=group --B.sub.1 --X--B.sub.2 --, wherein X=O or C.sub.1 -C.sub.4 alkylene;--NH--R=amine residue or alcohol residue; andR', R"=C.sub.1 -C.sub.5 alkyl, H or hydrophobic radical, and their addition salts with mineral or organic acids, method of preparation, applications, especially to visualization, purification, the preparation of antibodies and the assay of the total hormone, and as drugs, compositions in which they are present and analytical kits.
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