发明授权
US5312728A Assays and kits incorporating nucleic acid probes containing improved
molecular switch
失效
包含含有改进的分子开关的核酸探针的测定和试剂盒
- 专利标题： Assays and kits incorporating nucleic acid probes containing improved molecular switch
- 专利标题（中）： 包含含有改进的分子开关的核酸探针的测定和试剂盒
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申请号： US878230申请日： 1992-05-04
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公开(公告)号： US5312728A公开(公告)日： 1994-05-17
- 发明人: Paul M. Lizardi , Fred R. Kramer , Sanjay Tyagi , Cesar E. Guerra , Hilda M. L. Buyoli , Barbara C. Chu , Gerald F. Joyce , Leslie E. Orgel
- 申请人： Paul M. Lizardi , Fred R. Kramer , Sanjay Tyagi , Cesar E. Guerra , Hilda M. L. Buyoli , Barbara C. Chu , Gerald F. Joyce , Leslie E. Orgel
- 申请人地址： NY New York CA San Diego
- 专利权人： Public Health Research Institute of the City of New York, Inc.,The Salk Institute for Biological Studies
- 当前专利权人： Public Health Research Institute of the City of New York, Inc.,The Salk Institute for Biological Studies
- 当前专利权人地址： NY New York CA San Diego
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; C12Q1/68 ; C12P19/34
摘要：
A probe for the detection of a nucleic acid target sequence containing a molecular switch comprising three essential elements: a probe sequence of 20-60 nucleotides surrounded by switch sequences of 10-40 nucleotides which are complementary to each other, wherein the state of the switch is useful for selectively generating a detectable signal if the probe is hybridized to a target; also, assays and kits utilizing such probes.
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