发明授权
US5324655A Human Y-interferon signal peptide-tumor necrosis factor(TNF) gene fusions
失效
人γ-干扰素信号肽 - 肿瘤坏死因子（TNF）基因融合
- 专利标题： Human Y-interferon signal peptide-tumor necrosis factor(TNF) gene fusions
- 专利标题（中）： 人γ-干扰素信号肽 - 肿瘤坏死因子（TNF）基因融合
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申请号： US839017申请日： 1992-02-18
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公开(公告)号： US5324655A公开(公告)日： 1994-06-28
- 发明人: Michael Kriegler , Carl Perez
- 申请人： Michael Kriegler , Carl Perez
- 申请人地址： CA Emeryville
- 专利权人： Cetus Oncology Corporation
- 当前专利权人： Cetus Oncology Corporation
- 当前专利权人地址： CA Emeryville
- 主分类号： C12N5/10
- IPC分类号： C12N5/10 ; A01N63/00 ; A61K9/50 ; A61K35/76 ; A61K38/00 ; A61K38/19 ; A61K38/21 ; A61K38/22 ; A61K48/00 ; A61P35/00 ; C07K14/47 ; C07K14/525 ; C07K14/57 ; C12N5/08 ; C12N5/22 ; C12N7/00 ; C12N15/09 ; C12N15/19 ; C12N15/23 ; C12N15/28 ; C12N15/48 ; C12N15/867 ; C12P21/02 ; C12R1/91 ; C12R1/92 ; C12N15/11 ; C12N15/63
摘要：
A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferred virions are those that carry an RNA sequence that encodes cytokines or lymphokines, and includes IL-2, multiple drug resistance protein, and TNF. Particularly disclosed is a DNA construct in which a gene encoding tumor necrosis factor (TNF) is directly linked to DNA encoding a human .gamma.-interferon signal peptide.
公开/授权文献
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