发明授权
US5332739A Pyrimidinedione derivatives and antiarrhythmic agents containing same
失效
嘧啶二酮衍生物和含有它们的抗心律失常药
- 专利标题: Pyrimidinedione derivatives and antiarrhythmic agents containing same
- 专利标题(中): 嘧啶二酮衍生物和含有它们的抗心律失常药
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申请号: US971059申请日: 1992-11-02
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公开(公告)号: US5332739A公开(公告)日: 1994-07-26
- 发明人: Tsutomu Katakami , Tatsuro Yokoyama , Michihiko Miyamoto , Haruki Mori , Nobuya Kawauchi , Tadahito Nobori , Joji Kamiya , Masaaki Ishii
- 申请人: Tsutomu Katakami , Tatsuro Yokoyama , Michihiko Miyamoto , Haruki Mori , Nobuya Kawauchi , Tadahito Nobori , Joji Kamiya , Masaaki Ishii
- 申请人地址: JPX Tokyo
- 专利权人: Mitsui Toatsu Chemicals, Incorporated
- 当前专利权人: Mitsui Toatsu Chemicals, Incorporated
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX2-112710 19900427; JPX2-336080 19901113
- 主分类号: C07D239/54
- IPC分类号: C07D239/54 ; A61K31/505 ; A61P9/00 ; A61P9/06 ; C07D239/545 ; C07D401/12 ; C07D403/12 ; C07D405/12 ; A61K31/50 ; C07D239/42 ; C07D403/04
摘要:
Pyrimidinedione derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 is so linked with each other as to make an alkylene chain and thus form a heterocyclic structure, A, R.sup.3, R.sup.4, X.sup.1, X.sup.2 and X.sup.3 are substituents, respectively, and n is 2 or 3 have a basic backbone in which a phenyl group part and a pyrimidinedione part are linked by a structure comprising an alkyl chain and a heterocyclic ring having two nitrogen atoms. These compounds are useful for a medical treatment of cardiac arrhythmias.