A door frame having excellent fire-resistance, flexural strength and screw holding properties is fabricated from gypsum fiberboard, specifically a gypsum fiberboard having a density of at least 60 lbs./cu.ft., a flexural strength of at least about 30 lbs. (1/2" thick material), and a screw holding capability of at least about 400 lbs. A preferred gypsum fiberboard material for fabrication of the door frame comprises a composition containing a substantially uniform dispersion of solids including by weight about 65% to 90% set gypsum, about 7% to about 30% pulped paper, up to about 9% binder, and about 0.8% to 2% inorganic fiber. A wood veneer is preferably applied to the visible faces of the gypsum fiberboard door frame members.