发明授权
- 专利标题： Endotherlin antagonists
- 专利标题（中）： 吸热素拮抗剂
-
申请号： US995480申请日： 1992-12-21
-
公开(公告)号： US5382569A公开(公告)日： 1995-01-17
- 发明人: Wayne L. Cody , Patricia DePue , Annette M. Doherty , John X. He , Michael D. Taylor
- 申请人： Wayne L. Cody , Patricia DePue , Annette M. Doherty , John X. He , Michael D. Taylor
- 申请人地址： NJ Morris Plains
- 专利权人： Warner-Lambert Company
- 当前专利权人： Warner-Lambert Company
- 当前专利权人地址： NJ Morris Plains
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61P3/00 ; A61P3/08 ; A61P9/00 ; A61P9/06 ; A61P9/08 ; A61P9/10 ; A61P9/12 ; A61P11/00 ; A61P13/02 ; A61P15/00 ; A61P25/00 ; A61P35/00 ; C07K1/00 ; C07K5/10 ; C07K5/107 ; C07K7/06 ; C07K14/575 ; A61K37/02
摘要：
Novel antagonists of endothelin are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, metabolic, endocrinological, neurological disorders, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, Raynaud's disease, percutaneous transluminal coronary angioplasty or restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, ischemic bowel disease, and diabetes.
公开/授权文献
信息查询
IPC分类:
