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公开(公告)号：US20250051389A1
公开(公告)日：2025-02-13
申请号：US18404263
申请日：2024-01-04
Applicant: Stealth BioTherapeutics Inc.
Inventor： Liping Liu , Lawrence Gu
IPC: C07K5/11 , A61K38/00 , C07K5/06 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/087 , C07K5/09 , C07K5/107 , G01N30/02 , G01N33/50 , G01N33/68 , H01J49/00
Abstract: The disclosure provides compositions and methods relating to aromatic-cationic peptides. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof. For example, the peptides may be administered to subjects in need of a mitochondrial-targeted antioxidant.
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公开(公告)号：US12215173B2
公开(公告)日：2025-02-04
申请号：US16988229
申请日：2020-08-07
Applicant: Humanwell Pharmaceutical US
Inventor： Subo Liao , Jun Yang , Jinliang Lv , Zongquan Liao , Hao Zhou , Jueyuan Gao , Tianpeng Xie , Quanli Yang , Lei Wang , Zejian Ding
Abstract: The present invention provides kappa opioid receptor peptide agonists, methods for preparing these compounds, compositions comprising these kappa opioid receptor peptide agonists, and methods of using the kappa opioid receptor peptide agonists to treat pain or other conditions.
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公开(公告)号：US12102659B2
公开(公告)日：2024-10-01
申请号：US18079604
申请日：2022-12-12
Applicant: Cornell University , University of Washington
Inventor： Hazel H. Szeto , Peter S. Rabinovitch , Dao-Fu Dai
CPC classification number: A61K38/07 , A61K9/0019 , A61K45/06 , A61P9/00 , C07K5/0817 , C07K5/1016 , C07K5/1019 , A61K38/07 , A61K2300/00
Abstract: The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof.
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公开(公告)号：US12076363B2
公开(公告)日：2024-09-03
申请号：US17482699
申请日：2021-09-23
Applicant: ONYX PHARMACEUTICALS, INC.
Inventor： Shirin Kapur , Alana Lerner , Christopher J. Kirk , Eric Lowe , Tracey Lin
IPC: A61K38/07 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/4545 , A61K31/4745 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K38/04 , A61K38/06 , A61K38/08 , A61K45/06 , C07K5/083 , C07K5/107
CPC classification number: A61K38/07 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/4545 , A61K31/4745 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K38/04 , A61K38/06 , A61K38/08 , A61K45/06 , C07K5/081 , C07K5/1016 , A61K38/06 , A61K2300/00 , A61K38/07 , A61K2300/00 , A61K31/4745 , A61K2300/00 , A61K31/5025 , A61K2300/00 , A61K31/426 , A61K2300/00 , A61K31/5377 , A61K2300/00 , A61K31/506 , A61K2300/00 , A61K31/4545 , A61K2300/00 , A61K31/427 , A61K2300/00 , A61K31/454 , A61K2300/00
Abstract: This disclosure provides methods of treating a cancer in a patient using a peptide epoxyketone proteasome inhibitor in combination with a PIM kinase inhibitor.
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公开(公告)号：US20240252863A1
公开(公告)日：2024-08-01
申请号：US18633704
申请日：2024-04-12
Applicant: The Reliable Automatic Sprinkler Co. Inc.
Inventor： Thomas Multer
IPC: A62C37/11 , A61K38/00 , A62C3/00 , A62C35/60 , A62C35/62 , A62C35/68 , A62C37/14 , C07C51/41 , C07C53/18 , C07D301/00 , C07D301/03 , C07D303/36 , C07K1/107 , C07K1/30 , C07K5/087 , C07K5/103 , C07K5/107
CPC classification number: A62C37/11 , A62C3/004 , A62C35/68 , C07C51/412 , C07C53/18 , C07D301/00 , C07D301/03 , C07D303/36 , C07K1/1075 , C07K1/306 , C07K5/0812 , C07K5/1008 , C07K5/1016 , A61K38/00 , A62C35/60 , A62C35/62 , A62C37/14
Abstract: A dry fire protection sprinkler in which, when a ratio of a pressure P1 of a pressurized fluid in a flexible tube to a pressure P3 of the fluid in a fluid supply line is less than a predetermined ratio of at least 3 to 1, a differential pressure controller sends a signal to a control valve to open, in order to allow the pressurized fluid in a pressurized fluid source at a pressure of P2 to enter the flexible tube, and, when the ratio of the pressure P1 of the pressurized fluid in the flexible tube to the pressure P3 of the fluid in the fluid supply line equals the predetermined ratio, the differential pressure controller sends a signal to the control valve to close.
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Patent Agency Ranking
公开(公告)号：US11998781B2
公开(公告)日：2024-06-04
申请号：US18340095
申请日：2023-06-23
Applicant: The Reliable Automatic Sprinkler Co. Inc.
Inventor： Thomas Multer
IPC: A62C37/11 , A62C3/00 , A62C35/60 , A62C35/62 , A62C35/68 , A62C37/14 , C07C51/41 , C07C53/18 , C07D301/00 , C07D301/03 , C07D303/36 , C07K1/107 , C07K1/30 , C07K5/087 , C07K5/103 , C07K5/107 , A61K38/00
CPC classification number: A62C37/11 , A62C3/004 , A62C35/68 , C07C51/412 , C07C53/18 , C07D301/00 , C07D301/03 , C07D303/36 , C07K1/1075 , C07K1/306 , C07K5/0812 , C07K5/1008 , C07K5/1016 , A61K38/00 , A62C35/60 , A62C35/62 , A62C37/14
Abstract: A dry fire protection sprinkler in which, when a ratio of a pressure P1 of a pressurized fluid in a flexible tube to a pressure P3 of the fluid in a fluid supply line is less than a predetermined ratio of at least 3 to 1, a differential pressure controller sends a signal to a control valve to open, in order to allow the pressurized fluid in a pressurized fluid source at a pressure of P2 to enter the flexible tube, and, when the ratio of the pressure P1 of the pressurized fluid in the flexible tube to the pressure P3 of the fluid in the fluid supply line equals the predetermined ratio, the differential pressure controller sends a signal to the control valve to close.
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公开(公告)号：US20240150399A1
公开(公告)日：2024-05-09
申请号：US18412769
申请日：2024-01-15
Applicant: MICROSINTESIS INC.
Inventor： Monica Angela Cella , Sarah M. Curtis , Jonathon Patrick Roepke
IPC: C07K7/06 , A23L33/18 , A23L33/195 , A61L15/46 , A61L27/54 , A61L29/16 , A61L31/16 , C07K5/107 , C07K5/113
CPC classification number: C07K7/06 , A23L33/18 , A23L33/195 , A61L15/46 , A61L27/54 , A61L29/16 , A61L31/16 , C07K5/1016 , C07K5/1021 , A61K38/00
Abstract: Provided are peptides that are derived from probiotic bacteria that have use for preventing and/or treating non-enteric infections in a subject. The peptides derived from the probiotic bacteria also have use for reducing the virulence of non-enteric infections in a subject. Also provided are compositions of the peptides formulated as or within food products, beverages, nutritional supplements, medicaments and the like.
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公开(公告)号：US20240092832A1
公开(公告)日：2024-03-21
申请号：US18120648
申请日：2023-03-13
Applicant: Stealth BioTherapeutics Inc.
Inventor： Guozhu Zheng
CPC classification number: C07K5/1016 , A61P13/12 , A61K38/00
Abstract: Disclosed are deuterated analogs of SBT-20 and elamipretide (MTP-131). The compounds are useful for the treatment and prevention of ischemia-reperfusion injury (e.g., cardiac ischemia-reperfusion injury) or myocardial infarction.
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公开(公告)号：US20230398172A1
公开(公告)日：2023-12-14
申请号：US18115847
申请日：2023-08-30
Applicant: Cornell University
Inventor： Hazel H. SZETO , Diane FELSEN
CPC classification number: A61K38/07 , C07K5/1019 , C07K5/1016 , A61K38/06 , A61K38/00
Abstract: The disclosure relates to a method for protecting a kidney from renal injury. For example, acute renal injury may be associated with decreased or blocked blood flow in the subject's kidney or exposure to a nephrotoxic agent, such as a radiocontrast dye. The methods include administering to the subject an effective amount of an aromatic-cationic peptide to a subject in need thereof.
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公开(公告)号：US20230381264A1
公开(公告)日：2023-11-30
申请号：US18448650
申请日：2023-08-11
Applicant: Stealth BioTherapeutics Inc.
Inventor： Liping Liu , Shibo Tang , Xiaoling Liang
CPC classification number: A61K38/06 , C07K5/0817 , A61K38/07 , C07K5/1016 , A61P27/02 , A61K45/06 , A61P27/12
Abstract: The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
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