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公开(公告)号：US5641752A
公开(公告)日：1997-06-24
申请号：US316533
申请日：1994-09-30
申请人： Wayne Livingston Cody , Patricia DePue , Annette Marian Doherty , John Xiaoqiang He , Michael Douglas Taylor
发明人： Wayne Livingston Cody , Patricia DePue , Annette Marian Doherty , John Xiaoqiang He , Michael Douglas Taylor
IPC分类号： A61K38/00 , A61P3/00 , A61P3/08 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P35/00 , C07K1/00 , C07K5/10 , C07K5/107 , C07K7/06 , C07K14/575 , C07K5/00 , C07K7/00
CPC分类号： C07K7/06 , C07K14/57536 , C07K5/1016 , A61K38/00
摘要： Novel antagonists of endothelin are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, metabolic, endocrinological, neurological disorders, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, Raynaud's disease, percutaneous transluminal coronary angioplasty or restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, ischemic bowel disease, and diabetes.
摘要翻译： 描述了内皮素的新型拮抗剂，以及其制备方法及其药物组合物，其可用于治疗高水平的内皮素，急性和慢性肾衰竭，高血压，心肌梗塞，代谢，内分泌，神经障碍，充血性 心脏衰竭，内毒素性休克，蛛网膜下腔出血，心律失常，哮喘，先兆子痫，雷诺氏病，经皮腔内冠状动脉成形术或再狭窄，心绞痛，癌症，肺动脉高压，缺血性疾病，胃粘膜损伤，缺血性肠病和糖尿病。
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公开(公告)号：US5382569A
公开(公告)日：1995-01-17
申请号：US995480
申请日：1992-12-21
IPC分类号： A61K38/00 , A61P3/00 , A61P3/08 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P35/00 , C07K1/00 , C07K5/10 , C07K5/107 , C07K7/06 , C07K14/575 , A61K37/02
CPC分类号： C07K7/06 , C07K14/57536 , C07K5/1016 , A61K38/00
摘要： Novel antagonists of endothelin are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, metabolic, endocrinological, neurological disorders, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, Raynaud's disease, percutaneous transluminal coronary angioplasty or restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, ischemic bowel disease, and diabetes.
摘要翻译： 描述了内皮素的新型拮抗剂，以及其制备方法及其药物组合物，其可用于治疗高水平的内皮素，急性和慢性肾衰竭，高血压，心肌梗塞，代谢，内分泌，神经障碍，充血性 心脏衰竭，内毒素性休克，蛛网膜下腔出血，心律失常，哮喘，先兆子痫，雷诺氏病，经皮腔内冠状动脉成形术或再狭窄，心绞痛，癌症，肺动脉高压，缺血性疾病，胃粘膜损伤，缺血性肠病和糖尿病。
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公开(公告)号：US5773414A
公开(公告)日：1998-06-30
申请号：US813625
申请日：1997-03-07
申请人： Wayne Livingston Cody , Patricia DePue , Annette Marian Doherty , John Xiaoqiang He , Michael Douglas Taylor
发明人： Wayne Livingston Cody , Patricia DePue , Annette Marian Doherty , John Xiaoqiang He , Michael Douglas Taylor
IPC分类号： A61K38/00 , A61P3/00 , A61P3/08 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/00 , A61P35/00 , C07K1/00 , C07K5/10 , C07K5/107 , C07K7/06 , C07K14/575 , A61K38/02 , C07K5/00 , C07K7/00
CPC分类号： C07K7/06 , C07K14/57536 , C07K5/1016 , A61K38/00
摘要： Novel antagonists of endothelin are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, metabolic, endocrinological, neurological disorders, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, Raynaud's disease, percutaneous transluminal coronary angioplasty or restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, ischemic bowel disease, and diabetes.
摘要翻译： 描述了内皮素的新型拮抗剂，以及其制备方法及其药物组合物，其可用于治疗高水平的内皮素，急性和慢性肾衰竭，高血压，心肌梗塞，代谢，内分泌，神经障碍，充血性 心脏衰竭，内毒素性休克，蛛网膜下腔出血，心律失常，哮喘，先兆子痫，雷诺氏病，经皮腔内冠状动脉成形术或再狭窄，心绞痛，癌症，肺动脉高压，缺血性疾病，胃粘膜损伤，缺血性肠病和糖尿病。
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