发明授权
- 专利标题: Iodinated aromatic compounds
- 专利标题(中): 碘化芳族化合物
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申请号: US285595申请日: 1994-08-03
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公开(公告)号: US5384107A公开(公告)日: 1995-01-24
- 发明人: Baldev Singh , Edward R. Bacon , Carl R. Illig
- 申请人: Baldev Singh , Edward R. Bacon , Carl R. Illig
- 申请人地址: NY New York
- 专利权人: Sterling Winthrop Inc.
- 当前专利权人: Sterling Winthrop Inc.
- 当前专利权人地址: NY New York
- 主分类号: C07C57/52
- IPC分类号: C07C57/52 ; A61K49/04 ; C07C233/54 ; C07C233/88 ; C07C255/55
摘要:
Compounds having the structure ##STR1## wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 6;R.sup.1 and R.sup.2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy;R.sup.3 and R.sup.4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy or acylamino;Q represents the atoms necessary to complete a carbocyclic or heterocyclic unsaturated mono- or bicyclic aromatic ring; andR.sup.5 is H, alkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, amino, acylamino, alkoxyalkyl, fluoroalkyl, acetamidoalkyl, COO-alkyl, cyano, carboxamido, sulfonate, sulfonamido, ureido, or carbamyl are useful as contrast agents in x-ray imaging compositions and methods.
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